Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase

Medicine & Life Sciences

• Purine-Nucleoside Phosphorylase 100%
• Thermodynamics 78%
• 4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)immucillin G 77%
• Catalytic Domain 58%
• Cattle 51%
• Mutation 36%
• Biochemistry 28%
• Kinetics 23%
• Guanosine 20%
• Catalysis 19%
• Manuscripts 18%
• Isotopes 17%
• Amino Acid Sequence 14%
• Temperature 11%
• Amino Acids 11%
• Enzymes 8%

Chemical Compounds

• Purine Nucleoside 83%
• Transition State Structure 81%
• Biochemistry 59%
• Mutation 54%
• Thermodynamics 39%
• Inhibition Constant 39%
• Guanosine 35%
• Isotope Effect 32%
• Amino Acid Sequence 29%
• Thermodynamic Property 28%
• Transition State 26%
• Catalysis 20%
• Crystal Structure 16%
• Acid 11%