Altered patterns of evoked synaptic activity in cortical pyramidal neurons in feline ganglioside storage disease

A. B. Karabelas, Steven U. Walkley

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Postsynaptic potentials evoked by ventrolateral thalamic stimulation were recorded intracellularly from neurons in the precruciate cortex of GM1 mutants with HRP- or LY-loaded microelectrodes. Ganglioside-laden pyramidal neurons exhibiting somal distention and/or meganeurite formation were found to respond to thalamic stimulation with short duration IPSPs. Evoked EPSPs were recorded from two morphologically characterized large basket intrinsic neurons which deployed extensive intracortical axonal arborizations. These findings point to the preservation of intracortical inhibitory networks in the feline model of GM1 gangliosidosis, and to the possibility of abnormal integration of somadendritic inputs in ganglioside-laden pyramidal neurons.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalBrain Research
Volume339
Issue number2
DOIs
StatePublished - Jul 29 1985

Fingerprint

Gangliosidoses
Gangliosides
Pyramidal Cells
Felidae
GM1 Gangliosidosis
Neurons
Inhibitory Postsynaptic Potentials
Synaptic Potentials
Excitatory Postsynaptic Potentials
Microelectrodes

Keywords

  • ganglioside storage disease
  • intracortical inhibition
  • large basket cells
  • pyramidal neurons
  • thalamocortical input

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Altered patterns of evoked synaptic activity in cortical pyramidal neurons in feline ganglioside storage disease. / Karabelas, A. B.; Walkley, Steven U.

In: Brain Research, Vol. 339, No. 2, 29.07.1985, p. 329-336.

Research output: Contribution to journalArticle

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