Altered immune function in autism

Gina Delgiudice-Asch, Eric Hollander

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Recent studies of the pathogenesis of autism have suggested that this disorder may have an autoimmune basis in some patients. Observations have been made regarding cellular and humoral immune dysfunction, abnormalities associated with the complement system and major histocompatibility complex gene expression, differences in soluble mediators of the immune response, and the presence of antibrain and antimyelin autoantibodies. In this article, we review these experimental and clinical observations, and examine preliminary efforts using immunomodulatory therapies to treat autism.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalCNS Spectrums
Volume2
Issue number5
StatePublished - 1997
Externally publishedYes

Fingerprint

Autistic Disorder
Immunomodulation
Major Histocompatibility Complex
Autoantibodies
Gene Expression

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Delgiudice-Asch, G., & Hollander, E. (1997). Altered immune function in autism. CNS Spectrums, 2(5), 61-68.

Altered immune function in autism. / Delgiudice-Asch, Gina; Hollander, Eric.

In: CNS Spectrums, Vol. 2, No. 5, 1997, p. 61-68.

Research output: Contribution to journalArticle

Delgiudice-Asch, G & Hollander, E 1997, 'Altered immune function in autism', CNS Spectrums, vol. 2, no. 5, pp. 61-68.
Delgiudice-Asch, Gina ; Hollander, Eric. / Altered immune function in autism. In: CNS Spectrums. 1997 ; Vol. 2, No. 5. pp. 61-68.
@article{ee02a3ea734440858d5f9788af212cea,
title = "Altered immune function in autism",
abstract = "Recent studies of the pathogenesis of autism have suggested that this disorder may have an autoimmune basis in some patients. Observations have been made regarding cellular and humoral immune dysfunction, abnormalities associated with the complement system and major histocompatibility complex gene expression, differences in soluble mediators of the immune response, and the presence of antibrain and antimyelin autoantibodies. In this article, we review these experimental and clinical observations, and examine preliminary efforts using immunomodulatory therapies to treat autism.",
author = "Gina Delgiudice-Asch and Eric Hollander",
year = "1997",
language = "English (US)",
volume = "2",
pages = "61--68",
journal = "CNS Spectrums",
issn = "1092-8529",
publisher = "MBL Communications",
number = "5",

}

TY - JOUR

T1 - Altered immune function in autism

AU - Delgiudice-Asch, Gina

AU - Hollander, Eric

PY - 1997

Y1 - 1997

N2 - Recent studies of the pathogenesis of autism have suggested that this disorder may have an autoimmune basis in some patients. Observations have been made regarding cellular and humoral immune dysfunction, abnormalities associated with the complement system and major histocompatibility complex gene expression, differences in soluble mediators of the immune response, and the presence of antibrain and antimyelin autoantibodies. In this article, we review these experimental and clinical observations, and examine preliminary efforts using immunomodulatory therapies to treat autism.

AB - Recent studies of the pathogenesis of autism have suggested that this disorder may have an autoimmune basis in some patients. Observations have been made regarding cellular and humoral immune dysfunction, abnormalities associated with the complement system and major histocompatibility complex gene expression, differences in soluble mediators of the immune response, and the presence of antibrain and antimyelin autoantibodies. In this article, we review these experimental and clinical observations, and examine preliminary efforts using immunomodulatory therapies to treat autism.

UR - http://www.scopus.com/inward/record.url?scp=0002991204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002991204&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0002991204

VL - 2

SP - 61

EP - 68

JO - CNS Spectrums

JF - CNS Spectrums

SN - 1092-8529

IS - 5

ER -