Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma

B. Hilda Ye, Florigio Lista, Francesco Lo Coco, Daniel M. Knowles, Kenneth Offit, R. S K Chaganti, Riccardo Dalla-Favera

Research output: Contribution to journalArticle

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Abstract

The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6gene is truncated within its 5′ noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.

Original languageEnglish (US)
Pages (from-to)747-750
Number of pages4
JournalScience
Volume262
Issue number5134
StatePublished - 1993
Externally publishedYes

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Lymphoma, Large B-Cell, Diffuse
Zinc Fingers
Genes
Genetic Translocation
Proto-Oncogenes
Lymphoma
Transcription Factors
Neoplasms
Proteins

ASJC Scopus subject areas

  • General

Cite this

Ye, B. H., Lista, F., Lo Coco, F., Knowles, D. M., Offit, K., Chaganti, R. S. K., & Dalla-Favera, R. (1993). Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science, 262(5134), 747-750.

Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. / Ye, B. Hilda; Lista, Florigio; Lo Coco, Francesco; Knowles, Daniel M.; Offit, Kenneth; Chaganti, R. S K; Dalla-Favera, Riccardo.

In: Science, Vol. 262, No. 5134, 1993, p. 747-750.

Research output: Contribution to journalArticle

Ye, BH, Lista, F, Lo Coco, F, Knowles, DM, Offit, K, Chaganti, RSK & Dalla-Favera, R 1993, 'Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma', Science, vol. 262, no. 5134, pp. 747-750.
Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RSK et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science. 1993;262(5134):747-750.
Ye, B. Hilda ; Lista, Florigio ; Lo Coco, Francesco ; Knowles, Daniel M. ; Offit, Kenneth ; Chaganti, R. S K ; Dalla-Favera, Riccardo. / Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. In: Science. 1993 ; Vol. 262, No. 5134. pp. 747-750.
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AU - Chaganti, R. S K

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