TY - JOUR
T1 - Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
AU - Ye, Bihui H.
AU - Lista, Florigio
AU - Lo Coco, Francesco
AU - Knowles, Daniel M.
AU - Offit, Kenneth
AU - Chaganti, R. S.K.
AU - Dalla-Favera, Riccardo
PY - 1993
Y1 - 1993
N2 - The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5′ noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.
AB - The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5′ noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.
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U2 - 10.1126/science.8235596
DO - 10.1126/science.8235596
M3 - Article
C2 - 8235596
AN - SCOPUS:0027495491
SN - 0036-8075
VL - 262
SP - 747
EP - 750
JO - Science
JF - Science
IS - 5134
ER -