Alterations in the ribosomal machinery in cancer and hematologic disorders

Niraj Shenoy, Rachel Kessel, Tushar D. Bhagat, Sanchari Bhattacharyya, Yiting Yu, Christine McMahon, Amit Verma

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Ribosomes are essential components of the protein translation machinery and are composed of more than 80 unique large and small ribosomal proteins. Recent studies show that in addition to their roles in protein translation, ribosomal proteins are also involved in extra-ribosomal functions of DNA repair, apoptosis and cellular homeostasis. Consequently, alterations in the synthesis or functioning of ribosomal proteins can lead to various hematologic disorders. These include congenital anemias such as Diamond Blackfan anemia and Shwachman Diamond syndrome; both of which are associated with mutations in various ribosomal genes. Acquired uniallelic deletion of RPS14 gene has also been shown to lead to the 5q syndrome, a distinct subset of MDS associated with macrocytic anemia. Recent evidence shows that specific ribosomal proteins are overexpressed in liver, colon, prostate and other tumors. Ribosomal protein overexpression can promote tumorigenesis by interactions with the p53 tumor suppressor pathway and also by direct effects on various oncogenes. These data point to a broad role of ribosome protein alterations in hematologic and oncologic diseases.

Original languageEnglish (US)
Article number32
JournalJournal of Hematology and Oncology
Volume5
DOIs
StatePublished - 2012

Fingerprint

Ribosomal Proteins
Diamond-Blackfan Anemia
Protein Biosynthesis
Neoplasms
Ribosomes
Macrocytic Anemia
Hematologic Diseases
Gene Deletion
Ribosomal DNA
Oncogenes
DNA Repair
Anemia
Prostate
Colon
Carcinogenesis
Homeostasis
Apoptosis
Mutation
Liver
Genes

Keywords

  • Anemia
  • MDS
  • Ribosome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research
  • Molecular Biology

Cite this

Alterations in the ribosomal machinery in cancer and hematologic disorders. / Shenoy, Niraj; Kessel, Rachel; Bhagat, Tushar D.; Bhattacharyya, Sanchari; Yu, Yiting; McMahon, Christine; Verma, Amit.

In: Journal of Hematology and Oncology, Vol. 5, 32, 2012.

Research output: Contribution to journalArticle

@article{9de4d56ddd7f4e11835c01140fc01b26,
title = "Alterations in the ribosomal machinery in cancer and hematologic disorders",
abstract = "Ribosomes are essential components of the protein translation machinery and are composed of more than 80 unique large and small ribosomal proteins. Recent studies show that in addition to their roles in protein translation, ribosomal proteins are also involved in extra-ribosomal functions of DNA repair, apoptosis and cellular homeostasis. Consequently, alterations in the synthesis or functioning of ribosomal proteins can lead to various hematologic disorders. These include congenital anemias such as Diamond Blackfan anemia and Shwachman Diamond syndrome; both of which are associated with mutations in various ribosomal genes. Acquired uniallelic deletion of RPS14 gene has also been shown to lead to the 5q syndrome, a distinct subset of MDS associated with macrocytic anemia. Recent evidence shows that specific ribosomal proteins are overexpressed in liver, colon, prostate and other tumors. Ribosomal protein overexpression can promote tumorigenesis by interactions with the p53 tumor suppressor pathway and also by direct effects on various oncogenes. These data point to a broad role of ribosome protein alterations in hematologic and oncologic diseases.",
keywords = "Anemia, MDS, Ribosome",
author = "Niraj Shenoy and Rachel Kessel and Bhagat, {Tushar D.} and Sanchari Bhattacharyya and Yiting Yu and Christine McMahon and Amit Verma",
year = "2012",
doi = "10.1186/1756-8722-5-32",
language = "English (US)",
volume = "5",
journal = "Journal of Hematology and Oncology",
issn = "1756-8722",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Alterations in the ribosomal machinery in cancer and hematologic disorders

AU - Shenoy, Niraj

AU - Kessel, Rachel

AU - Bhagat, Tushar D.

AU - Bhattacharyya, Sanchari

AU - Yu, Yiting

AU - McMahon, Christine

AU - Verma, Amit

PY - 2012

Y1 - 2012

N2 - Ribosomes are essential components of the protein translation machinery and are composed of more than 80 unique large and small ribosomal proteins. Recent studies show that in addition to their roles in protein translation, ribosomal proteins are also involved in extra-ribosomal functions of DNA repair, apoptosis and cellular homeostasis. Consequently, alterations in the synthesis or functioning of ribosomal proteins can lead to various hematologic disorders. These include congenital anemias such as Diamond Blackfan anemia and Shwachman Diamond syndrome; both of which are associated with mutations in various ribosomal genes. Acquired uniallelic deletion of RPS14 gene has also been shown to lead to the 5q syndrome, a distinct subset of MDS associated with macrocytic anemia. Recent evidence shows that specific ribosomal proteins are overexpressed in liver, colon, prostate and other tumors. Ribosomal protein overexpression can promote tumorigenesis by interactions with the p53 tumor suppressor pathway and also by direct effects on various oncogenes. These data point to a broad role of ribosome protein alterations in hematologic and oncologic diseases.

AB - Ribosomes are essential components of the protein translation machinery and are composed of more than 80 unique large and small ribosomal proteins. Recent studies show that in addition to their roles in protein translation, ribosomal proteins are also involved in extra-ribosomal functions of DNA repair, apoptosis and cellular homeostasis. Consequently, alterations in the synthesis or functioning of ribosomal proteins can lead to various hematologic disorders. These include congenital anemias such as Diamond Blackfan anemia and Shwachman Diamond syndrome; both of which are associated with mutations in various ribosomal genes. Acquired uniallelic deletion of RPS14 gene has also been shown to lead to the 5q syndrome, a distinct subset of MDS associated with macrocytic anemia. Recent evidence shows that specific ribosomal proteins are overexpressed in liver, colon, prostate and other tumors. Ribosomal protein overexpression can promote tumorigenesis by interactions with the p53 tumor suppressor pathway and also by direct effects on various oncogenes. These data point to a broad role of ribosome protein alterations in hematologic and oncologic diseases.

KW - Anemia

KW - MDS

KW - Ribosome

UR - http://www.scopus.com/inward/record.url?scp=84862256740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862256740&partnerID=8YFLogxK

U2 - 10.1186/1756-8722-5-32

DO - 10.1186/1756-8722-5-32

M3 - Article

C2 - 22709827

AN - SCOPUS:84862256740

VL - 5

JO - Journal of Hematology and Oncology

JF - Journal of Hematology and Oncology

SN - 1756-8722

M1 - 32

ER -