Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

Jin S. Im, Tae Jin Kang, Seong Beom Lee, Chi Hong Kim, Sang Haak Lee, Manjunatha M. Venkataswamy, Evan R. Serfass, Bing Chen, Petr A. Illarionov, Gurdyal S. Besra, William R. Jacobs, Gue Tae Chae, Steven A. Porcelli

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4-CD8β- (DN) iNKT cells with a proportionate increase in the CD4+ iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.

Original languageEnglish (US)
Pages (from-to)214-224
Number of pages11
JournalClinical Immunology
Volume127
Issue number2
DOIs
StatePublished - May 2008

Fingerprint

Natural Killer T-Cells
T-Lymphocyte Subsets
Infection
Leprosy
Mycobacterium tuberculosis
Mycobacterium leprae
Tuberculosis
Mycobacterium Infections
Regulatory T-Lymphocytes
Communicable Diseases
Chronic Disease
T-Lymphocytes

Keywords

  • α-Galactosylceramide
  • CD1d
  • Glycolipid
  • Invariant natural killer T cells
  • Leprosy
  • Mycobacteria
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections. / Im, Jin S.; Kang, Tae Jin; Lee, Seong Beom; Kim, Chi Hong; Lee, Sang Haak; Venkataswamy, Manjunatha M.; Serfass, Evan R.; Chen, Bing; Illarionov, Petr A.; Besra, Gurdyal S.; Jacobs, William R.; Chae, Gue Tae; Porcelli, Steven A.

In: Clinical Immunology, Vol. 127, No. 2, 05.2008, p. 214-224.

Research output: Contribution to journalArticle

Im, JS, Kang, TJ, Lee, SB, Kim, CH, Lee, SH, Venkataswamy, MM, Serfass, ER, Chen, B, Illarionov, PA, Besra, GS, Jacobs, WR, Chae, GT & Porcelli, SA 2008, 'Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections', Clinical Immunology, vol. 127, no. 2, pp. 214-224. https://doi.org/10.1016/j.clim.2007.12.005
Im, Jin S. ; Kang, Tae Jin ; Lee, Seong Beom ; Kim, Chi Hong ; Lee, Sang Haak ; Venkataswamy, Manjunatha M. ; Serfass, Evan R. ; Chen, Bing ; Illarionov, Petr A. ; Besra, Gurdyal S. ; Jacobs, William R. ; Chae, Gue Tae ; Porcelli, Steven A. / Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections. In: Clinical Immunology. 2008 ; Vol. 127, No. 2. pp. 214-224.
@article{74eab182013946749007ea9e75e5e808,
title = "Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections",
abstract = "CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4-CD8β- (DN) iNKT cells with a proportionate increase in the CD4+ iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.",
keywords = "α-Galactosylceramide, CD1d, Glycolipid, Invariant natural killer T cells, Leprosy, Mycobacteria, Tuberculosis",
author = "Im, {Jin S.} and Kang, {Tae Jin} and Lee, {Seong Beom} and Kim, {Chi Hong} and Lee, {Sang Haak} and Venkataswamy, {Manjunatha M.} and Serfass, {Evan R.} and Bing Chen and Illarionov, {Petr A.} and Besra, {Gurdyal S.} and Jacobs, {William R.} and Chae, {Gue Tae} and Porcelli, {Steven A.}",
year = "2008",
month = "5",
doi = "10.1016/j.clim.2007.12.005",
language = "English (US)",
volume = "127",
pages = "214--224",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

AU - Im, Jin S.

AU - Kang, Tae Jin

AU - Lee, Seong Beom

AU - Kim, Chi Hong

AU - Lee, Sang Haak

AU - Venkataswamy, Manjunatha M.

AU - Serfass, Evan R.

AU - Chen, Bing

AU - Illarionov, Petr A.

AU - Besra, Gurdyal S.

AU - Jacobs, William R.

AU - Chae, Gue Tae

AU - Porcelli, Steven A.

PY - 2008/5

Y1 - 2008/5

N2 - CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4-CD8β- (DN) iNKT cells with a proportionate increase in the CD4+ iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.

AB - CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4-CD8β- (DN) iNKT cells with a proportionate increase in the CD4+ iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.

KW - α-Galactosylceramide

KW - CD1d

KW - Glycolipid

KW - Invariant natural killer T cells

KW - Leprosy

KW - Mycobacteria

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=41549168084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41549168084&partnerID=8YFLogxK

U2 - 10.1016/j.clim.2007.12.005

DO - 10.1016/j.clim.2007.12.005

M3 - Article

C2 - 18308638

AN - SCOPUS:41549168084

VL - 127

SP - 214

EP - 224

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 2

ER -