Alteration of the penile corpora in patients with erectile impotence

A. Melman, D. P. Henry, D. L. Felten, B. L. O'Connor

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We measured the content of the two principal neurotransmitters of the autonomic nervous system from the erectile tissue of four men with normal erection and 38 men impotent as a result of injury or disease. In the former the norepinephrine content was 812 ± 82.6 (SE) pg per mg of wet weight. In the latter, statistically significant reductions of norepinephrine were found with the greatest decrease occurring with insulin-dependent diabetes mellitus. Neither choline acetyltransferase activity nor morphologic alterations of the nerve fibers of erectile tissue were observed in either group. Our findings suggest that the sympathetic nervous system is an integral component of human erection and that a functional alteration of the corporal nerve fibers occurs with several diseases associated with impotence.

Original languageEnglish (US)
Pages (from-to)474-477
Number of pages4
JournalInvestigative Urology
Volume17
Issue number6
StatePublished - 1980
Externally publishedYes

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Erectile Dysfunction
Nerve Fibers
Norepinephrine
Choline O-Acetyltransferase
Autonomic Nervous System
Sympathetic Nervous System
Type 1 Diabetes Mellitus
Neurotransmitter Agents
Weights and Measures
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Melman, A., Henry, D. P., Felten, D. L., & O'Connor, B. L. (1980). Alteration of the penile corpora in patients with erectile impotence. Investigative Urology, 17(6), 474-477.

Alteration of the penile corpora in patients with erectile impotence. / Melman, A.; Henry, D. P.; Felten, D. L.; O'Connor, B. L.

In: Investigative Urology, Vol. 17, No. 6, 1980, p. 474-477.

Research output: Contribution to journalArticle

Melman, A, Henry, DP, Felten, DL & O'Connor, BL 1980, 'Alteration of the penile corpora in patients with erectile impotence', Investigative Urology, vol. 17, no. 6, pp. 474-477.
Melman A, Henry DP, Felten DL, O'Connor BL. Alteration of the penile corpora in patients with erectile impotence. Investigative Urology. 1980;17(6):474-477.
Melman, A. ; Henry, D. P. ; Felten, D. L. ; O'Connor, B. L. / Alteration of the penile corpora in patients with erectile impotence. In: Investigative Urology. 1980 ; Vol. 17, No. 6. pp. 474-477.
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