Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia

Steven M. Devine, Ron Hoffman, Amit Verma, Rajul Shah, Basil A. Bradlow, Wendy Stock, Vera Maynard, Ellen Jessop, David Peace, Marianne Huml, Deana Thomason, Yi Hsiang Chen, Koen Van Besien

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

Standard myeloablative conditioning prior to allogeneic hematopoietic stem cell (HSC) transplantation has been associated with significant toxicity in patients older than 45 years of age with myelofibrosis with myeloid metaplasia (MMM). We sought to evaluate the efficacy of a reduced-intensity conditioning regimen for allogeneic HSC transplantation in this setting. A regimen consisting of fludarabine (30 mg/m2 intravenously daily for 5 days) and melphalan (70 mg/m2 intravenously daily for 2 days) followed by transplantation of filgrastim-mobilized peripheral blood cells from HLA-identical siblings was administered to 4 older patients (median age, 56 years; range, 48-58 years) with advanced MMM. All patients achieved prompt neutrophil and platelet engraftment and have experienced a significant regression of splenomegaly and bone marrow fibrosis. All now have normal bone marrow cellularity. With a median follow-up of 13 months (range, 11-19 months), all 4 patients are alive with stable full-donor hematopoietic chimerism. These results support the feasibility and effectiveness of reduced-intensity conditioning prior to allogeneic HSC transplantation for older patients with advanced MMM.

Original languageEnglish (US)
Pages (from-to)2255-2258
Number of pages4
JournalBlood
Volume99
Issue number6
DOIs
StatePublished - Mar 15 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Devine, S. M., Hoffman, R., Verma, A., Shah, R., Bradlow, B. A., Stock, W., Maynard, V., Jessop, E., Peace, D., Huml, M., Thomason, D., Chen, Y. H., & Van Besien, K. (2002). Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. Blood, 99(6), 2255-2258. https://doi.org/10.1182/blood.V99.6.2255