TY - JOUR
T1 - Allicin and Digestive System Cancers
T2 - From Chemical Structure to Its Therapeutic Opportunities
AU - Sarvizadeh, Mahshad
AU - Hasanpour, Omid
AU - Naderi Ghale-Noie, Zari
AU - Mollazadeh, Samaneh
AU - Rezaei, Mohammad
AU - Pourghadamyari, Hossein
AU - Masoud Khooy, Mohammadjaber
AU - Aschner, Michael
AU - Khan, Haroon
AU - Rezaei, Nima
AU - Shojaie, Layla
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© Copyright © 2021 Sarvizadeh, Hasanpour, Naderi Ghale-Noie, Mollazadeh, Rezaei, Pourghadamyari, Masoud Khooy, Aschner, Khan, Rezaei, Shojaie and Mirzaei.
PY - 2021/4/27
Y1 - 2021/4/27
N2 - Digestive system cancer tumors are one of the major causes of cancer-related fatalities; the vast majority of them are colorectal or gastric malignancies. Epidemiological evidence confirmed that allium-containing food, such as garlic, reduces the risk of developing malignancies. Among all compounds in garlic, allicin has been most researched, as it contains sulfur and produces many second degradation compounds, such as sulfur dioxide, diallyl sulfide (DAS), diallyl trisulfide (DATS), and diallyl disulfide (DADS) in the presence of enzymatic reactions in gastric juice. These substances have shown anti-inflammatory, antidiabetic, antihypertensive, antifungal, antiviral, antibacterial, and anticancer efficacy, including gastrointestinal (GI) cancers, leukemia, and skin cancers. Herein, we summarize the therapeutic potential of allicin in the treatment of GI cancers.
AB - Digestive system cancer tumors are one of the major causes of cancer-related fatalities; the vast majority of them are colorectal or gastric malignancies. Epidemiological evidence confirmed that allium-containing food, such as garlic, reduces the risk of developing malignancies. Among all compounds in garlic, allicin has been most researched, as it contains sulfur and produces many second degradation compounds, such as sulfur dioxide, diallyl sulfide (DAS), diallyl trisulfide (DATS), and diallyl disulfide (DADS) in the presence of enzymatic reactions in gastric juice. These substances have shown anti-inflammatory, antidiabetic, antihypertensive, antifungal, antiviral, antibacterial, and anticancer efficacy, including gastrointestinal (GI) cancers, leukemia, and skin cancers. Herein, we summarize the therapeutic potential of allicin in the treatment of GI cancers.
KW - allicin
KW - chemical structure
KW - gastrointenstinal cancer
KW - natural compounds
KW - therapy
UR - http://www.scopus.com/inward/record.url?scp=85105633961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105633961&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.650256
DO - 10.3389/fonc.2021.650256
M3 - Review article
AN - SCOPUS:85105633961
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 650256
ER -
