@article{791aac7fa88d44b9996be378d9e579ee,
title = "All-trans retinoic acid and late relapses in acute promyelocytic leukemia: Very long-term follow-up of the North American Intergroup Study I0129",
abstract = "We report a long-term follow-up (median 11.8 years) of the First North American Intergroup Study. 379 patients were randomized to induction with ATRA or to chemotherapy. All complete responders (CR) received consolidation chemotherapy, then randomized to 1 year ATRA or observation. 245 patients received ATRA sometime during the study: 195 (80%) achieved a CR. Nine (4.6%) relapsed late (>3 years from CR), the last occurred after 4.6 years; 7 of them were still alive after 5.5-15 years. In APL patients, late relapses are uncommon, and those who sustain CR >5 years can be considered cured.",
keywords = "Acute promyelocytic leukemia, All-trans retinoic acid, Late relapse",
author = "Dan Douer and Zickl, {Lynette N.} and Schiffer, {Charles A.} and Appelbaum, {Fredrick R.} and Feusner, {James H.} and Lois Shepherd and Willman, {Cheryl L.} and Bloomfield, {Clara D.} and Elisabeth Paietta and Gallagher, {Robert E.} and Park, {Jae H.} and Rowe, {Jacob M.} and Wiernik, {Peter H.} and Tallman, {Martin S.}",
note = "Funding Information: This study was coordinated by the Eastern Cooperative Oncology Group (Robert L. Comis, M.D., Chair) and supported in part by Public Health Service Grants CA21115, CA23318, CA66636, CA17145, CA14958, CA77658, CA32102, CA 37027, CA12213 and from the National Cancer Institute, National Institutes of Health and the Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute. Research support for the study: CA021115 and CA114737 were awarded to EP and CA56771 to REG. ",
year = "2013",
month = jul,
doi = "10.1016/j.leukres.2013.03.001",
language = "English (US)",
volume = "37",
pages = "795--801",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "7",
}