Alcohol Intoxication Effects on Visual Perception

An fMRI Study

Vince D. Calhoun, David J. Altschul, Vince McGinty, Regina Shih, David Scott, Edie Sears, Godfrey D. Pearlson

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

We examined the effects of two doses of alcohol (EtOH) on functional magnetic resonance imaging (fMRI) activation during a visual perception task. The Motor-Free Visual Perception Test-Revised (MVPT-R) provides measures of overall visual perceptual processing ability. It incorporates different cognitive elements including visual discrimination, spatial relationships, and mental rotation. We used the MVPT-R to study brain activation patterns in healthy controls (1) sober, and (2) at two doses of alcohol intoxication with event-related fMRI. The fMRI data were analyzed using a general linear model approach based upon a model of the time course and a hemodynamic response estimate. Additionally, a correlation analysis was performed to examine dose-dependent amplitude changes. With regard to alcohol-free task-related brain activation, we replicate our previous finding in which SPM group analysis revealed robust activation in visual and visual association areas, frontal eye field (FEF)/dorsolateral prefrontal cortex (DLPFC), and the supplemental motor area (SMA). Consistent with a previous study of EtOH and visual stimulation, EtOH resulted in a dose-dependent decrease in activation amplitude over much of the visual perception network and in a decrease in the maximum contrast-to-noise ratio (in the lingual gyrus). Despite only modest behavior changes (in the expected direction), significant dose-dependent activation increases were observed in insula, DLPFC, and precentral regions, whereas dose-dependent activation decreases were observed in anterior and posterior cingulate, precuneus, and middle frontal areas. Some areas (FEF/DLPFC/SMA) became more diffusely activated (i.e., increased in spatial extent) at the higher dose. Alcohol, thus, appears to have both global and local effects upon the neural correlates of the MVPT-R task, some of which are dose dependent.

Original languageEnglish (US)
Pages (from-to)15-25
Number of pages11
JournalHuman Brain Mapping
Volume21
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Fingerprint

Alcoholic Intoxication
Visual Perception
Magnetic Resonance Imaging
Prefrontal Cortex
Gyrus Cinguli
Alcohols
Motor Cortex
Frontal Lobe
Occipital Lobe
Photic Stimulation
Parietal Lobe
Aptitude
Brain
Noise
Linear Models
Hemodynamics

Keywords

  • Alcohol
  • Brain
  • fMRI
  • Functional
  • Visual perception

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Calhoun, V. D., Altschul, D. J., McGinty, V., Shih, R., Scott, D., Sears, E., & Pearlson, G. D. (2004). Alcohol Intoxication Effects on Visual Perception: An fMRI Study. Human Brain Mapping, 21(1), 15-25. https://doi.org/10.1002/hbm.10145

Alcohol Intoxication Effects on Visual Perception : An fMRI Study. / Calhoun, Vince D.; Altschul, David J.; McGinty, Vince; Shih, Regina; Scott, David; Sears, Edie; Pearlson, Godfrey D.

In: Human Brain Mapping, Vol. 21, No. 1, 01.2004, p. 15-25.

Research output: Contribution to journalArticle

Calhoun, VD, Altschul, DJ, McGinty, V, Shih, R, Scott, D, Sears, E & Pearlson, GD 2004, 'Alcohol Intoxication Effects on Visual Perception: An fMRI Study', Human Brain Mapping, vol. 21, no. 1, pp. 15-25. https://doi.org/10.1002/hbm.10145
Calhoun, Vince D. ; Altschul, David J. ; McGinty, Vince ; Shih, Regina ; Scott, David ; Sears, Edie ; Pearlson, Godfrey D. / Alcohol Intoxication Effects on Visual Perception : An fMRI Study. In: Human Brain Mapping. 2004 ; Vol. 21, No. 1. pp. 15-25.
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