Alcohol consumption and risk of lung cancer

A pooled analysis of cohort studies

Jo L. Freudenheim, John Ritz, Stephanie A. Smith-Warner, Demetrius Albanes, Elisa V. Bandera, Piet A. Van Den Brandt, Graham Colditz, Diane Feskanich, R. Alexandra Goldbohm, Lisa Harnack, Anthony B. Miller, Eric Rimm, Thomas E. Rohan, Thomas A. Sellers, Jarmo Virtamo, Walter C. Willett, David J. Hunter

Research output: Contribution to journalArticle

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Abstract

Background: Although smoking is the primary cause of lung cancer, much is unknown about lung cancer etiology, including risk determinants for nonsmokers and modifying factors for smokers. Objective: We hypothesized that alcohol consumption contributes to lung cancer risk. Design: We conducted a pooled analysis using standardized exposure and covariate data from 7 prospective studies with 399 767 participants and 3137 lung cancer cases. Study-specific relative risks (RRs) and CIs were estimated and then combined to calculate pooled multivariate RRs by using a random-effects model. Results: We found a slightly greater risk for the consumption of ≥30 g alcohol/d than for that of 0 g alcohol/d in men (RR: 1.21; 95% CI: 0.91, 1.61; P for trend = 0.03) and in women (RR: 1.16; 95% CI: 0.94, 1.43; P for trend = 0.03). In male never smokers, the RR for consumption of ≥ 15 g alcohol/d rather than 0 g alcohol/d was 6.38 (95% CI: 2.74, 14.9; P for trend < 0.001). In women, there were few never-smoking cases and no evidence of greater risk (RR: 1.35; 95% CI: 0.64, 2.87). Because of possible residual confounding by smoking, we performed sensitivity analyses by reclassifying the never smokers in the highest drinking category as former smokers. Resulting associations for alcohol consumption were somewhat attenuated, but P for trend = 0.05 for men, which was near the original P = 0.03. Conclusions: A slightly greater risk of lung cancer was associated with the consumption of ≥30 g alcohol/d than with no alcohol consumption. Alcohol consumption was strongly associated with greater risk in male never smokers. Residual confounding by smoking may explain part of the observed relation.

Original languageEnglish (US)
Pages (from-to)657-667
Number of pages11
JournalAmerican Journal of Clinical Nutrition
Volume82
Issue number3
StatePublished - 2005

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relative risk
lung neoplasms
cohort studies
Alcohol Drinking
Lung Neoplasms
Cohort Studies
alcohols
Alcohols
Smoking
prospective studies
drinking
etiology
alcohol drinking
Drinking
Prospective Studies

Keywords

  • Alcohol consumption
  • Diet
  • Epidemiology
  • Lung neoplasms
  • Meta-analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Freudenheim, J. L., Ritz, J., Smith-Warner, S. A., Albanes, D., Bandera, E. V., Van Den Brandt, P. A., ... Hunter, D. J. (2005). Alcohol consumption and risk of lung cancer: A pooled analysis of cohort studies. American Journal of Clinical Nutrition, 82(3), 657-667.

Alcohol consumption and risk of lung cancer : A pooled analysis of cohort studies. / Freudenheim, Jo L.; Ritz, John; Smith-Warner, Stephanie A.; Albanes, Demetrius; Bandera, Elisa V.; Van Den Brandt, Piet A.; Colditz, Graham; Feskanich, Diane; Goldbohm, R. Alexandra; Harnack, Lisa; Miller, Anthony B.; Rimm, Eric; Rohan, Thomas E.; Sellers, Thomas A.; Virtamo, Jarmo; Willett, Walter C.; Hunter, David J.

In: American Journal of Clinical Nutrition, Vol. 82, No. 3, 2005, p. 657-667.

Research output: Contribution to journalArticle

Freudenheim, JL, Ritz, J, Smith-Warner, SA, Albanes, D, Bandera, EV, Van Den Brandt, PA, Colditz, G, Feskanich, D, Goldbohm, RA, Harnack, L, Miller, AB, Rimm, E, Rohan, TE, Sellers, TA, Virtamo, J, Willett, WC & Hunter, DJ 2005, 'Alcohol consumption and risk of lung cancer: A pooled analysis of cohort studies', American Journal of Clinical Nutrition, vol. 82, no. 3, pp. 657-667.
Freudenheim JL, Ritz J, Smith-Warner SA, Albanes D, Bandera EV, Van Den Brandt PA et al. Alcohol consumption and risk of lung cancer: A pooled analysis of cohort studies. American Journal of Clinical Nutrition. 2005;82(3):657-667.
Freudenheim, Jo L. ; Ritz, John ; Smith-Warner, Stephanie A. ; Albanes, Demetrius ; Bandera, Elisa V. ; Van Den Brandt, Piet A. ; Colditz, Graham ; Feskanich, Diane ; Goldbohm, R. Alexandra ; Harnack, Lisa ; Miller, Anthony B. ; Rimm, Eric ; Rohan, Thomas E. ; Sellers, Thomas A. ; Virtamo, Jarmo ; Willett, Walter C. ; Hunter, David J. / Alcohol consumption and risk of lung cancer : A pooled analysis of cohort studies. In: American Journal of Clinical Nutrition. 2005 ; Vol. 82, No. 3. pp. 657-667.
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abstract = "Background: Although smoking is the primary cause of lung cancer, much is unknown about lung cancer etiology, including risk determinants for nonsmokers and modifying factors for smokers. Objective: We hypothesized that alcohol consumption contributes to lung cancer risk. Design: We conducted a pooled analysis using standardized exposure and covariate data from 7 prospective studies with 399 767 participants and 3137 lung cancer cases. Study-specific relative risks (RRs) and CIs were estimated and then combined to calculate pooled multivariate RRs by using a random-effects model. Results: We found a slightly greater risk for the consumption of ≥30 g alcohol/d than for that of 0 g alcohol/d in men (RR: 1.21; 95{\%} CI: 0.91, 1.61; P for trend = 0.03) and in women (RR: 1.16; 95{\%} CI: 0.94, 1.43; P for trend = 0.03). In male never smokers, the RR for consumption of ≥ 15 g alcohol/d rather than 0 g alcohol/d was 6.38 (95{\%} CI: 2.74, 14.9; P for trend < 0.001). In women, there were few never-smoking cases and no evidence of greater risk (RR: 1.35; 95{\%} CI: 0.64, 2.87). Because of possible residual confounding by smoking, we performed sensitivity analyses by reclassifying the never smokers in the highest drinking category as former smokers. Resulting associations for alcohol consumption were somewhat attenuated, but P for trend = 0.05 for men, which was near the original P = 0.03. Conclusions: A slightly greater risk of lung cancer was associated with the consumption of ≥30 g alcohol/d than with no alcohol consumption. Alcohol consumption was strongly associated with greater risk in male never smokers. Residual confounding by smoking may explain part of the observed relation.",
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T2 - A pooled analysis of cohort studies

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AU - Ritz, John

AU - Smith-Warner, Stephanie A.

AU - Albanes, Demetrius

AU - Bandera, Elisa V.

AU - Van Den Brandt, Piet A.

AU - Colditz, Graham

AU - Feskanich, Diane

AU - Goldbohm, R. Alexandra

AU - Harnack, Lisa

AU - Miller, Anthony B.

AU - Rimm, Eric

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AU - Virtamo, Jarmo

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AU - Hunter, David J.

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KW - Alcohol consumption

KW - Diet

KW - Epidemiology

KW - Lung neoplasms

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