TY - JOUR
T1 - Alcohol consumption and risk of breast cancer
T2 - A cohort study
AU - Rohan, Thomas E.
AU - Jain, Meera
AU - Howe, Geoffrey R.
AU - Miller, Anthony B.
N1 - Funding Information:
This work was supported by a grant from the National Cancer Institute of Canada (Grant no. 7394). We thank Mr Andrew White for preparing the data file for statistical analysis.
PY - 2000
Y1 - 2000
N2 - Objectives: To study the association between alcohol consumption and breast cancer risk. Methods: A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study (NBSS) and who completed a self-administered dietary questionnaire. (The NBSS is a randomized controlled trial of screening for breast cancer in women aged 40-59 at recruitment.) The cohort was recruited between 1980 and 1985, and during follow-up to the end of 1993 a total of 1469 women in the dietary cohort were diagnosed with biopsy-confirmed incident breast cancer. For comparative purposes a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons the analyses were based on 1336 cases and 5238 noncases. Results: When compared to nondrinkers the adjusted incidence rate ratios (95% confidence intervals) for those consuming > 0 and ≤ 10 g of alcohol/day, > 10 and ≤ 20 g/day, > 20 and ≤ 30 g/day, > 30 and ≤ 40 g/day, > 40 and ≤ 50 g/day, and > 50 g/day were 1.01 (0.84-1.22), 1.16 (0.91-1.47), 1.27 (0.91-1.78), 0.77 (0.51-1.16), 1.00 (0.57-1.75), and 1.70 (0.97-2.98), respectively; the associated p value for the test for trend was 0.351. Similar findings were obtained when analyses were conducted separately in the screened and control arms of the NBSS, in premenopausal and postmenopausal women, for screen-detected and interval-detected breast cancer, and by levels of other breast cancer risk factors. Conclusions: The results of this study suggest that alcohol consumption might be associated with increased risk of breast cancer at relatively high levels of intake.
AB - Objectives: To study the association between alcohol consumption and breast cancer risk. Methods: A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study (NBSS) and who completed a self-administered dietary questionnaire. (The NBSS is a randomized controlled trial of screening for breast cancer in women aged 40-59 at recruitment.) The cohort was recruited between 1980 and 1985, and during follow-up to the end of 1993 a total of 1469 women in the dietary cohort were diagnosed with biopsy-confirmed incident breast cancer. For comparative purposes a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons the analyses were based on 1336 cases and 5238 noncases. Results: When compared to nondrinkers the adjusted incidence rate ratios (95% confidence intervals) for those consuming > 0 and ≤ 10 g of alcohol/day, > 10 and ≤ 20 g/day, > 20 and ≤ 30 g/day, > 30 and ≤ 40 g/day, > 40 and ≤ 50 g/day, and > 50 g/day were 1.01 (0.84-1.22), 1.16 (0.91-1.47), 1.27 (0.91-1.78), 0.77 (0.51-1.16), 1.00 (0.57-1.75), and 1.70 (0.97-2.98), respectively; the associated p value for the test for trend was 0.351. Similar findings were obtained when analyses were conducted separately in the screened and control arms of the NBSS, in premenopausal and postmenopausal women, for screen-detected and interval-detected breast cancer, and by levels of other breast cancer risk factors. Conclusions: The results of this study suggest that alcohol consumption might be associated with increased risk of breast cancer at relatively high levels of intake.
KW - Alcohol
KW - Breast cancer
UR - http://www.scopus.com/inward/record.url?scp=0034108551&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034108551&partnerID=8YFLogxK
U2 - 10.1023/A:1008933824645
DO - 10.1023/A:1008933824645
M3 - Comment/debate
C2 - 10782658
AN - SCOPUS:0034108551
SN - 0957-5243
VL - 11
SP - 239
EP - 247
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 3
ER -