TY - JOUR
T1 - Albright's hereditary osteodystrophy and defective g proteins
AU - Spiegel, Allen M.
PY - 1990/5/17
Y1 - 1990/5/17
N2 - Given the myriad extracellular signals impinging on cells, the number of mechanisms used to convey information to them is surprisingly limited. A common feature is a signal discriminator, better known as a receptor. Often, the receptor is also an intracellular signal generator. Binding of an activating signal to the receptor triggers its intrinsic signal-generating capacity. An exception to this pattern is a large class of cell-surface receptors that are coupled to distinct intracellular signal generators by molecular go-betweens, called G proteins. G proteins are products of a large gene family. They specifically bind guanine nucleotides and hydrolyze the last phosphate.
AB - Given the myriad extracellular signals impinging on cells, the number of mechanisms used to convey information to them is surprisingly limited. A common feature is a signal discriminator, better known as a receptor. Often, the receptor is also an intracellular signal generator. Binding of an activating signal to the receptor triggers its intrinsic signal-generating capacity. An exception to this pattern is a large class of cell-surface receptors that are coupled to distinct intracellular signal generators by molecular go-betweens, called G proteins. G proteins are products of a large gene family. They specifically bind guanine nucleotides and hydrolyze the last phosphate.
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U2 - 10.1056/NEJM199005173222010
DO - 10.1056/NEJM199005173222010
M3 - Editorial
C2 - 2109829
AN - SCOPUS:0025326074
SN - 0028-4793
VL - 322
SP - 1461
EP - 1462
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 20
ER -