Aging, the central nervous system, and mobility

Andrea L. Rosso, Stephanie A. Studenski, Wen G. Chen, Howard J. Aizenstein, Neil B. Alexander, David A. Bennett, Sandra E. Black, Richard Camicioli, Michelle C. Carlson, Luigi Ferrucci, Jack M. Guralnik, Jeffrey M. Hausdorff, Jeff Kaye, Lenore J. Launer, Lewis A. Lipsitz, Joe Verghese, Caterina Rosano

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Background. Mobility limitations are common and hazardous in community-dwelling older adults but are largely understudied, particularly regarding the role of the central nervous system (CNS). This has limited development of clearly defined pathophysiology, clinical terminology, and effective treatments. Understanding how changes in the CNS contribute to mobility limitations has the potential to inform future intervention studies. Methods. A conference series was launched at the 2012 conference of the Gerontological Society of America in collaboration with the National Institute on Aging and the University of Pittsburgh. The overarching goal of the conference series is to facilitate the translation of research results into interventions that improve mobility for older adults. Results. Evidence from basic, clinical, and epidemiological studies supports the CNS as an important contributor to mobility limitations in older adults without overt neurologic disease. Three main goals for future work that emerged were as follows: (a) develop models of mobility limitations in older adults that differentiate aging from disease-related processes and that fully integrate CNS with musculoskeletal contributors; (b) quantify the contribution of the CNS to mobility loss in older adults in the absence of overt neurologic diseases; (c) promote cross-disciplinary collaboration to generate new ideas and address current methodological issues and barriers, including real-world mobility measures and life-course approaches. Conclusions. In addition to greater cross-disciplinary research, there is a need for new approaches to training clinicians and investigators, which integrate concepts and methodologies from individual disciplines, focus on emerging methodologies, and prepare investigators to assess complex, multisystem associations.

Original languageEnglish (US)
Pages (from-to)1379-1386
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number11
DOIs
StatePublished - Nov 2013

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Mobility Limitation
Central Nervous System
Nervous System Diseases
National Institute on Aging (U.S.)
Research Personnel
Independent Living
Research
Terminology
Epidemiologic Studies

Keywords

  • Central nervous system
  • Mobility
  • Motor control

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Rosso, A. L., Studenski, S. A., Chen, W. G., Aizenstein, H. J., Alexander, N. B., Bennett, D. A., ... Rosano, C. (2013). Aging, the central nervous system, and mobility. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 68(11), 1379-1386. https://doi.org/10.1093/gerona/glt089

Aging, the central nervous system, and mobility. / Rosso, Andrea L.; Studenski, Stephanie A.; Chen, Wen G.; Aizenstein, Howard J.; Alexander, Neil B.; Bennett, David A.; Black, Sandra E.; Camicioli, Richard; Carlson, Michelle C.; Ferrucci, Luigi; Guralnik, Jack M.; Hausdorff, Jeffrey M.; Kaye, Jeff; Launer, Lenore J.; Lipsitz, Lewis A.; Verghese, Joe; Rosano, Caterina.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 68, No. 11, 11.2013, p. 1379-1386.

Research output: Contribution to journalArticle

Rosso, AL, Studenski, SA, Chen, WG, Aizenstein, HJ, Alexander, NB, Bennett, DA, Black, SE, Camicioli, R, Carlson, MC, Ferrucci, L, Guralnik, JM, Hausdorff, JM, Kaye, J, Launer, LJ, Lipsitz, LA, Verghese, J & Rosano, C 2013, 'Aging, the central nervous system, and mobility', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 68, no. 11, pp. 1379-1386. https://doi.org/10.1093/gerona/glt089
Rosso AL, Studenski SA, Chen WG, Aizenstein HJ, Alexander NB, Bennett DA et al. Aging, the central nervous system, and mobility. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2013 Nov;68(11):1379-1386. https://doi.org/10.1093/gerona/glt089
Rosso, Andrea L. ; Studenski, Stephanie A. ; Chen, Wen G. ; Aizenstein, Howard J. ; Alexander, Neil B. ; Bennett, David A. ; Black, Sandra E. ; Camicioli, Richard ; Carlson, Michelle C. ; Ferrucci, Luigi ; Guralnik, Jack M. ; Hausdorff, Jeffrey M. ; Kaye, Jeff ; Launer, Lenore J. ; Lipsitz, Lewis A. ; Verghese, Joe ; Rosano, Caterina. / Aging, the central nervous system, and mobility. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2013 ; Vol. 68, No. 11. pp. 1379-1386.
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