Aging-shifted prostaglandin profile in endothelium as a factor in cardiovascular disorders

Hao Qian, Na Luo, Yuling Chi

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.

Original languageEnglish (US)
Article number121390
JournalJournal of Aging Research
Volume2012
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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