Aging

One thing leads to another

Marion Schmidt, Brian K. Kennedy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Mitochondria deteriorate during the aging process, but the underlying mechanisms for the decline of this critical organelle are unknown. A new study indicates that in yeast an age-dependent reduction in vacuolar acidification leads to mitochondrial dysfunction through a surprising mechanism: loss of vacuolar neutral amino acid transport.

Original languageEnglish (US)
JournalCurrent Biology
Volume22
Issue number24
DOIs
StatePublished - Dec 18 2012

Fingerprint

Neutral Amino Acids
Mitochondria
Acidification
Organelles
Yeast
acidification
organelles
mitochondria
Aging of materials
Yeasts
yeasts
amino acids

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Aging : One thing leads to another. / Schmidt, Marion; Kennedy, Brian K.

In: Current Biology, Vol. 22, No. 24, 18.12.2012.

Research output: Contribution to journalArticle

Schmidt, Marion ; Kennedy, Brian K. / Aging : One thing leads to another. In: Current Biology. 2012 ; Vol. 22, No. 24.
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