Aging on a different scale - chronological versus pathology-related aging

Joost P.M. Melis, Martijs J. Jonker, Jan Vijg, Jan H.J. Hoeijmakers, Timo M. Breit, Harry van Steeg

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In the next decades the elderly population will increase dramatically, demanding appropriate solutions in health care and aging research focusing on healthy aging to prevent high burdens and costs in health care. For this, research targeting tissue-specific and individual aging is paramount to make the necessary progression in aging research. In a recently published study we have attempted to make a step interpreting aging data on chronological as well as pathological scale. For this, we sampled five major tissues at regular time intervals during the entire C57BL/6J murine lifespan from a controlled in vivo aging study, measured the whole transcriptome and incorporated temporal as well as physical health aspects into the analyses. In total, we used 18 different age-related pathological parameters and transcriptomic profiles of liver, kidney, spleen, lung and brain and created a database that can now be used for a broad systems biology approach. In our study, we focused on the dynamics of biological processes during chronological aging and the comparison between chronological and pathology-related aging.

Original languageEnglish (US)
Pages (from-to)782-788
Number of pages7
JournalAging
Volume5
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • Aging
  • Diseases
  • Lipofuscin
  • Metabolism
  • Senescence
  • Signaling pathways

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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    Melis, J. P. M., Jonker, M. J., Vijg, J., Hoeijmakers, J. H. J., Breit, T. M., & van Steeg, H. (2013). Aging on a different scale - chronological versus pathology-related aging. Aging, 5(10), 782-788. https://doi.org/10.18632/aging.100606