Aging: A Sirtuin Shake-Up?

Research output: Contribution to journalShort survey

15 Scopus citations

Abstract

The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.

Original languageEnglish (US)
Pages (from-to)797-798
Number of pages2
JournalCell
Volume135
Issue number5
DOIs
StatePublished - Nov 28 2008

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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