Aggressive squamous cell carcinoma of the skin after chronic lymphocytic leukemia

Nancy Bridges, J. J. Steinberg

Research output: Contribution to journalArticle

20 Scopus citations


We report two cases of squamous cell carcinoma (SCC) of the skin subsequent to chronic lymphocytic leukemia (CLL). Both cases had an unusually aggressive course for a nonmelanoma skin malignancy with extensive metastases in both, resulting in death in one patient. A literature review supports the likelihood of an increased incidence of SCC in patients with CLL. Though the mechanism is unknown, immunosuppression may play a central role. We urge patients with CLL to avoid exposure to direct sun. Any questionable skin lesion should be biopsied early, and completely excised if it is a tumor. The patient should also be examined thoroughly for metastatic disease via subsequent follow‐up visits.

Original languageEnglish (US)
Pages (from-to)27-30
Number of pages4
JournalJournal of Surgical Oncology
Issue number1
StatePublished - Sep 1986


  • chemotherapy
  • chronic lymphocytic leukemia
  • radiation
  • second primary
  • squamous cell carcinoma of skin
  • ultra‐violet

ASJC Scopus subject areas

  • Surgery
  • Oncology

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