Aggravation of experimental glomerulonephritis by superimposed clip hypertension

Joel Neugarten, H. D. Feiner, R. G. Schacht, G. R. Gallo, D. S. Baldwin

Research output: Contribution to journalArticle

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Abstract

To evaluate the possible enhancing effect of hypertension on the clinical and morphologic features of glomerulonephritis, two-kidney clip hypertension (CH) was superimposed on a mild form of nephrotoxic serum nephritis (NSN) in female Sprague-Dawley rats. The following parameters were assessed regularly over a 6-month period: blood pressure (BP), heart weight, proteinuria (UpV), and renal morphology. Blood pressures and heart weights were increased equally in clip hypertension and in nephrotoxic serum nephritis combined with clip hypertension. While only moderate proteinuria occurred in nephrotoxic serum nephritis (49 ± 28 mg/24 hr) or clip hypertension (40 ± 22 mg/24 hr) alone, the superimposition of clip hypertension on nephrotoxic serum nephritis resulted in heavy proteinuria (161 ± 36 mg/24 hr) (P < 0.001) after 5 months of hypertension. Glomerular histology in nephrotoxic serum nephritis showed infrequent focal and segmental proliferation and minimal sclerosis; vessels were normal. Clip hypertension was characterized by infrequent and mild vascular sclerosis and glomerular proliferation and sclerosis. Severe glomerular endo- and extracapillary proliferation and widespread glomerular and vascular sclerosis occured in the majority of rats when nephrotoxic serum nephritis was combined with clip hypertension. The data demonstrate that clip hypertension enhances glomerular proliferation and sclerosis and results in the development of vascular sclerosis in experimental nephritis.

Original languageEnglish (US)
Pages (from-to)257-263
Number of pages7
JournalKidney International
Volume22
Issue number3
StatePublished - 1982
Externally publishedYes

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Glomerulonephritis
Surgical Instruments
Nephritis
Hypertension
Arteriosclerosis
Sclerosis
Serum
Proteinuria
Blood Pressure
Kidney
Weights and Measures
Sprague Dawley Rats
Histology

ASJC Scopus subject areas

  • Nephrology

Cite this

Neugarten, J., Feiner, H. D., Schacht, R. G., Gallo, G. R., & Baldwin, D. S. (1982). Aggravation of experimental glomerulonephritis by superimposed clip hypertension. Kidney International, 22(3), 257-263.

Aggravation of experimental glomerulonephritis by superimposed clip hypertension. / Neugarten, Joel; Feiner, H. D.; Schacht, R. G.; Gallo, G. R.; Baldwin, D. S.

In: Kidney International, Vol. 22, No. 3, 1982, p. 257-263.

Research output: Contribution to journalArticle

Neugarten, J, Feiner, HD, Schacht, RG, Gallo, GR & Baldwin, DS 1982, 'Aggravation of experimental glomerulonephritis by superimposed clip hypertension', Kidney International, vol. 22, no. 3, pp. 257-263.
Neugarten, Joel ; Feiner, H. D. ; Schacht, R. G. ; Gallo, G. R. ; Baldwin, D. S. / Aggravation of experimental glomerulonephritis by superimposed clip hypertension. In: Kidney International. 1982 ; Vol. 22, No. 3. pp. 257-263.
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