Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions

Xiao Dong; Shixiang Sun; Lei Zhang; Seungsoo Kim; Zhidong Tu; Cristina Montagna; Alexander Y. Maslov; Yousin Suh; Tao Wang; Judith Campisi; Jan Vijg

doi:10.1111/acel.13357

Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions

Xiao Dong, Shixiang Sun, Lei Zhang, Seungsoo Kim, Zhidong Tu, Cristina Montagna, Alexander Y. Maslov, Yousin Suh, Tao Wang, Judith Campisi, Jan Vijg

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.

Original language	English (US)
Article number	e13357
Journal	Aging cell
Volume	20
Issue number	6
DOIs	https://doi.org/10.1111/acel.13357
State	Published - Jun 2021

Keywords

aging
gene expression
telomere shortening

ASJC Scopus subject areas

Aging
Cell Biology

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10.1111/acel.13357

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title = "Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions",

abstract = "Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.",

keywords = "aging, gene expression, telomere shortening",

author = "Xiao Dong and Shixiang Sun and Lei Zhang and Seungsoo Kim and Zhidong Tu and Cristina Montagna and Maslov, {Alexander Y.} and Yousin Suh and Tao Wang and Judith Campisi and Jan Vijg",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.",

year = "2021",

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AU - Dong, Xiao

AU - Sun, Shixiang

AU - Zhang, Lei

AU - Kim, Seungsoo

AU - Tu, Zhidong

AU - Montagna, Cristina

AU - Maslov, Alexander Y.

AU - Suh, Yousin

AU - Wang, Tao

AU - Campisi, Judith

AU - Vijg, Jan

PY - 2021/6

Y1 - 2021/6

N2 - Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.

AB - Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.

KW - aging

KW - gene expression

KW - telomere shortening

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JO - Aging cell

JF - Aging cell

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ER -

Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions

Abstract

Keywords

ASJC Scopus subject areas

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