Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study.

P. J. Talmud, L. Berglund, E. M. Hawe, D. M. Waterworth, Carmen R. Isasi, R. E. Deckelbaum, T. Starc, H. N. Ginsberg, S. E. Humphries, S. Shea

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

OBJECTIVES: To examine the genotype:phenotype association in children compared with their parents. METHODS: Variations at 4 key gene loci, namely lipoprotein lipase (LPL S447X), hepatic lipase (HL -480C>T), cholesteryl ester transfer protein (CETP TaqIB), and apolipoprotein CIII (APOC3 -455T>C and -482C>T), were examined in children (n = 495) and their parents (n = 353) in the Columbia University BioMarkers Study, 1994 to 1998. RESULTS: The frequencies of the rare alleles of the HL -480C>T and APOC3 -455T>C and -482C>T (but not LPL S447X or CETP TaqIB) were significantly lower in non-Hispanic white participants compared with Hispanics. Overall, genotype effects seen in the adults were weaker in the children, although similar trends were seen. In an examination of the effect of body fat on the genotypic effects in the children, there was significant HL -480C>T:sum of skinfold interaction. CONCLUSIONS: All genotypes were associated with clear relationships to plasma lipid levels in adults, but the effects were weaker in their children, unless stressed by body fat. atherosclerosis, cardiovascular disease, child, lipids, genetics.

Original languageEnglish (US)
JournalPediatrics
Volume108
Issue number3
StatePublished - Sep 2001
Externally publishedYes

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Biomarkers
Lipids
Adipose Tissue
Parents
Genotype
Apolipoprotein C-III
Cholesterol Ester Transfer Proteins
Lipoprotein Lipase
Genetic Association Studies
Lipase
Hispanic Americans
Gene Frequency
Atherosclerosis
Cardiovascular Diseases
Liver
Genes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Talmud, P. J., Berglund, L., Hawe, E. M., Waterworth, D. M., Isasi, C. R., Deckelbaum, R. E., ... Shea, S. (2001). Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study. Pediatrics, 108(3).

Age-related effects of genetic variation on lipid levels : The Columbia University BioMarkers Study. / Talmud, P. J.; Berglund, L.; Hawe, E. M.; Waterworth, D. M.; Isasi, Carmen R.; Deckelbaum, R. E.; Starc, T.; Ginsberg, H. N.; Humphries, S. E.; Shea, S.

In: Pediatrics, Vol. 108, No. 3, 09.2001.

Research output: Contribution to journalArticle

Talmud, PJ, Berglund, L, Hawe, EM, Waterworth, DM, Isasi, CR, Deckelbaum, RE, Starc, T, Ginsberg, HN, Humphries, SE & Shea, S 2001, 'Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study.', Pediatrics, vol. 108, no. 3.
Talmud PJ, Berglund L, Hawe EM, Waterworth DM, Isasi CR, Deckelbaum RE et al. Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study. Pediatrics. 2001 Sep;108(3).
Talmud, P. J. ; Berglund, L. ; Hawe, E. M. ; Waterworth, D. M. ; Isasi, Carmen R. ; Deckelbaum, R. E. ; Starc, T. ; Ginsberg, H. N. ; Humphries, S. E. ; Shea, S. / Age-related effects of genetic variation on lipid levels : The Columbia University BioMarkers Study. In: Pediatrics. 2001 ; Vol. 108, No. 3.
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AU - Isasi, Carmen R.

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N2 - OBJECTIVES: To examine the genotype:phenotype association in children compared with their parents. METHODS: Variations at 4 key gene loci, namely lipoprotein lipase (LPL S447X), hepatic lipase (HL -480C>T), cholesteryl ester transfer protein (CETP TaqIB), and apolipoprotein CIII (APOC3 -455T>C and -482C>T), were examined in children (n = 495) and their parents (n = 353) in the Columbia University BioMarkers Study, 1994 to 1998. RESULTS: The frequencies of the rare alleles of the HL -480C>T and APOC3 -455T>C and -482C>T (but not LPL S447X or CETP TaqIB) were significantly lower in non-Hispanic white participants compared with Hispanics. Overall, genotype effects seen in the adults were weaker in the children, although similar trends were seen. In an examination of the effect of body fat on the genotypic effects in the children, there was significant HL -480C>T:sum of skinfold interaction. CONCLUSIONS: All genotypes were associated with clear relationships to plasma lipid levels in adults, but the effects were weaker in their children, unless stressed by body fat. atherosclerosis, cardiovascular disease, child, lipids, genetics.

AB - OBJECTIVES: To examine the genotype:phenotype association in children compared with their parents. METHODS: Variations at 4 key gene loci, namely lipoprotein lipase (LPL S447X), hepatic lipase (HL -480C>T), cholesteryl ester transfer protein (CETP TaqIB), and apolipoprotein CIII (APOC3 -455T>C and -482C>T), were examined in children (n = 495) and their parents (n = 353) in the Columbia University BioMarkers Study, 1994 to 1998. RESULTS: The frequencies of the rare alleles of the HL -480C>T and APOC3 -455T>C and -482C>T (but not LPL S447X or CETP TaqIB) were significantly lower in non-Hispanic white participants compared with Hispanics. Overall, genotype effects seen in the adults were weaker in the children, although similar trends were seen. In an examination of the effect of body fat on the genotypic effects in the children, there was significant HL -480C>T:sum of skinfold interaction. CONCLUSIONS: All genotypes were associated with clear relationships to plasma lipid levels in adults, but the effects were weaker in their children, unless stressed by body fat. atherosclerosis, cardiovascular disease, child, lipids, genetics.

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