Age-related differences in amplification of covalently closed circular DNA at early times after duck hepatitis B virus infection of ducks

Yong Yuan Zhang, Daniel P. Theele, Jesse Summers

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Inoculation of 3-day-old (3D) or 3-week-old (3W) ducklings with duck hepatitis B virus results in chronic or transient infection, respectively. We previously showed that rapid production of neutralizing antibody following inoculation of 3W ducklings prevents virus from spreading in the liver and leads to a transient infection (Y.-Y. Zhang and J. Summers, J. Virol. 78:1195-1201, 2004). In this study we further investigated early events of viral infection in both 3D and 3W ducks. We present evidence that a lower level of virus replication in the hepatocytes of 3W birds is an additional factor that probably favors transient infection. We suggest that lower virus replication is due to a less rapid covalently closed circular DNA amplification, leading to lower viremias and a slower spread of infection in the liver, and that the slower spread of infection in 3W ducks makes the infection more sensitive to interruption by the host immune responses.

Original languageEnglish (US)
Pages (from-to)9896-9903
Number of pages8
JournalJournal of virology
Volume79
Issue number15
DOIs
StatePublished - Aug 1 2005

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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