Age-dependent impact of fluoroscopic radiation on the gender of off-spring: An international survey of cardiologists

Jayasree Pillarisetti, Sowjanya Duthuluru, Hari Sayana, Haley Goucher, Akshar Patel, Mazda Biria, James Vacek, Loren Berenbom, Sudharani Bommana, Jayant Nath, Mark Wiley, Ajay Nangia, Luigi Di Biase, Andrea Natale, Madhuri Reddy, Buddhadeb Dawn, Dhanunjaya Lakkireddy

Research output: Contribution to journalArticle

Abstract

Background: Fluoroscopic radiation has been implicated in reducing the sex ratio (M:F) by potentially damaging the Y chromosome. We examined the effects of exposure to fluoroscopic radiation on gender of offspring of cardiologists across the world. Methods: An internet based survey was e-mailed worldwide to 8000 physicians who practice invasive electrophysiology and/or interventional cardiology. Survey questions included age, race, sub-specialty, hours of exposure to radiation, number of children, gender of off-spring, miscarriages and mutations and exposure to radiation prior to conception of each child. Logistic regression analyses were performed on years of exposure and gender of offspring born post radiation exposure. Results: Responses of 377 cardiologists (84% male and 16% female) were reviewed. With a total of 398 males and 402 females born to 377 cardiologists, although reduced, the overall sex ratio (0.99) was not significantly different from that observed in the general population (1.05). Univariate logistic regression analysis identified higher male births with increasing hours of radiation exposure (OR 1.034, CI 1.003-1.067 p=0.03) and increasing paternal age (OR 1.05, CI 1.01-1.08, p=0.002). Subgroup analysis of children of male cardiologists revealed higher incidence of male births with increasing age and radiation exposure and multivariate analysis only identified paternal age as predictor of higher incidence of male births (OR 1.05, CI 1.01-1.089, p=0.0027). Conclusion: Exposure to ionizing radiation leads to a decrease in the sex ratio (M/F) in younger male cardiologists, while this effect is reversed with greater number of male births in older male cardiologists.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalJournal of Atrial Fibrillation
Volume5
Issue number6
StatePublished - 2013
Externally publishedYes

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Radiation
Sex Ratio
Paternal Age
Parturition
Logistic Models
Regression Analysis
Background Radiation
Cardiologists
Surveys and Questionnaires
Electrophysiology
Y Chromosome
Incidence
Spontaneous Abortion
Ionizing Radiation
Cardiology
Internet
Multivariate Analysis
Radiation Exposure
Physicians
Mutation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pillarisetti, J., Duthuluru, S., Sayana, H., Goucher, H., Patel, A., Biria, M., ... Lakkireddy, D. (2013). Age-dependent impact of fluoroscopic radiation on the gender of off-spring: An international survey of cardiologists. Journal of Atrial Fibrillation, 5(6), 12-18.

Age-dependent impact of fluoroscopic radiation on the gender of off-spring : An international survey of cardiologists. / Pillarisetti, Jayasree; Duthuluru, Sowjanya; Sayana, Hari; Goucher, Haley; Patel, Akshar; Biria, Mazda; Vacek, James; Berenbom, Loren; Bommana, Sudharani; Nath, Jayant; Wiley, Mark; Nangia, Ajay; Di Biase, Luigi; Natale, Andrea; Reddy, Madhuri; Dawn, Buddhadeb; Lakkireddy, Dhanunjaya.

In: Journal of Atrial Fibrillation, Vol. 5, No. 6, 2013, p. 12-18.

Research output: Contribution to journalArticle

Pillarisetti, J, Duthuluru, S, Sayana, H, Goucher, H, Patel, A, Biria, M, Vacek, J, Berenbom, L, Bommana, S, Nath, J, Wiley, M, Nangia, A, Di Biase, L, Natale, A, Reddy, M, Dawn, B & Lakkireddy, D 2013, 'Age-dependent impact of fluoroscopic radiation on the gender of off-spring: An international survey of cardiologists', Journal of Atrial Fibrillation, vol. 5, no. 6, pp. 12-18.
Pillarisetti, Jayasree ; Duthuluru, Sowjanya ; Sayana, Hari ; Goucher, Haley ; Patel, Akshar ; Biria, Mazda ; Vacek, James ; Berenbom, Loren ; Bommana, Sudharani ; Nath, Jayant ; Wiley, Mark ; Nangia, Ajay ; Di Biase, Luigi ; Natale, Andrea ; Reddy, Madhuri ; Dawn, Buddhadeb ; Lakkireddy, Dhanunjaya. / Age-dependent impact of fluoroscopic radiation on the gender of off-spring : An international survey of cardiologists. In: Journal of Atrial Fibrillation. 2013 ; Vol. 5, No. 6. pp. 12-18.
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AU - Goucher, Haley

AU - Patel, Akshar

AU - Biria, Mazda

AU - Vacek, James

AU - Berenbom, Loren

AU - Bommana, Sudharani

AU - Nath, Jayant

AU - Wiley, Mark

AU - Nangia, Ajay

AU - Di Biase, Luigi

AU - Natale, Andrea

AU - Reddy, Madhuri

AU - Dawn, Buddhadeb

AU - Lakkireddy, Dhanunjaya

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N2 - Background: Fluoroscopic radiation has been implicated in reducing the sex ratio (M:F) by potentially damaging the Y chromosome. We examined the effects of exposure to fluoroscopic radiation on gender of offspring of cardiologists across the world. Methods: An internet based survey was e-mailed worldwide to 8000 physicians who practice invasive electrophysiology and/or interventional cardiology. Survey questions included age, race, sub-specialty, hours of exposure to radiation, number of children, gender of off-spring, miscarriages and mutations and exposure to radiation prior to conception of each child. Logistic regression analyses were performed on years of exposure and gender of offspring born post radiation exposure. Results: Responses of 377 cardiologists (84% male and 16% female) were reviewed. With a total of 398 males and 402 females born to 377 cardiologists, although reduced, the overall sex ratio (0.99) was not significantly different from that observed in the general population (1.05). Univariate logistic regression analysis identified higher male births with increasing hours of radiation exposure (OR 1.034, CI 1.003-1.067 p=0.03) and increasing paternal age (OR 1.05, CI 1.01-1.08, p=0.002). Subgroup analysis of children of male cardiologists revealed higher incidence of male births with increasing age and radiation exposure and multivariate analysis only identified paternal age as predictor of higher incidence of male births (OR 1.05, CI 1.01-1.089, p=0.0027). Conclusion: Exposure to ionizing radiation leads to a decrease in the sex ratio (M/F) in younger male cardiologists, while this effect is reversed with greater number of male births in older male cardiologists.

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