Age-dependent changes in HCNP-related antigen expression in the human hippocampus

Hiroyuki Yuasa; Kosei Ojika; Shigehisa Mitake; Eiichi Katada; Noriyuki Matsukawa; Yasushi Otsuka; Osamu Fujimori; Asao Hirano

doi:10.1016/S0165-3806(01)00097-9

Age-dependent changes in HCNP-related antigen expression in the human hippocampus

Hiroyuki Yuasa, Kosei Ojika, Shigehisa Mitake, Eiichi Katada, Noriyuki Matsukawa, Yasushi Otsuka, Osamu Fujimori, Asao Hirano

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from the young rat hippocampus, enhances the cholinergic phenotype development of the medial septal nucleus in vitro. In this study, we examined the HCNP-antigen distribution and the age-related changes in the number of positive cells in the hippocampus (obtained at autopsy from 74 subjects with no known neurological disorders). Immunohistochemical assay revealed that the immunopositive cells were GABAergic neurons and oligodendrocytes. They were first identified in the fetus at around 25 to 30 weeks and their number increased rapidly with advancing postconceptional age to reach maximal at the perinatal stage and in early postnatal life; it then decreased to the adult level by 10 years old. These results suggest that HCNP-related antigen may play important roles in the development and/or differentiation of the human hippocampus.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Developmental Brain Research
Volume	127
Issue number	1
DOIs	https://doi.org/10.1016/S0165-3806(01)00097-9
State	Published - Mar 29 2001
Externally published	Yes

Keywords

Aging
Development
HCNP
Hippocampal cholinergic neurostimulating peptide
Human hippocampus
Immunohistochemistry

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/S0165-3806(01)00097-9

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title = "Age-dependent changes in HCNP-related antigen expression in the human hippocampus",

abstract = "Hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from the young rat hippocampus, enhances the cholinergic phenotype development of the medial septal nucleus in vitro. In this study, we examined the HCNP-antigen distribution and the age-related changes in the number of positive cells in the hippocampus (obtained at autopsy from 74 subjects with no known neurological disorders). Immunohistochemical assay revealed that the immunopositive cells were GABAergic neurons and oligodendrocytes. They were first identified in the fetus at around 25 to 30 weeks and their number increased rapidly with advancing postconceptional age to reach maximal at the perinatal stage and in early postnatal life; it then decreased to the adult level by 10 years old. These results suggest that HCNP-related antigen may play important roles in the development and/or differentiation of the human hippocampus.",

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author = "Hiroyuki Yuasa and Kosei Ojika and Shigehisa Mitake and Eiichi Katada and Noriyuki Matsukawa and Yasushi Otsuka and Osamu Fujimori and Asao Hirano",

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AU - Yuasa, Hiroyuki

AU - Ojika, Kosei

AU - Mitake, Shigehisa

AU - Katada, Eiichi

AU - Matsukawa, Noriyuki

AU - Otsuka, Yasushi

AU - Fujimori, Osamu

AU - Hirano, Asao

PY - 2001/3/29

Y1 - 2001/3/29

N2 - Hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from the young rat hippocampus, enhances the cholinergic phenotype development of the medial septal nucleus in vitro. In this study, we examined the HCNP-antigen distribution and the age-related changes in the number of positive cells in the hippocampus (obtained at autopsy from 74 subjects with no known neurological disorders). Immunohistochemical assay revealed that the immunopositive cells were GABAergic neurons and oligodendrocytes. They were first identified in the fetus at around 25 to 30 weeks and their number increased rapidly with advancing postconceptional age to reach maximal at the perinatal stage and in early postnatal life; it then decreased to the adult level by 10 years old. These results suggest that HCNP-related antigen may play important roles in the development and/or differentiation of the human hippocampus.

AB - Hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from the young rat hippocampus, enhances the cholinergic phenotype development of the medial septal nucleus in vitro. In this study, we examined the HCNP-antigen distribution and the age-related changes in the number of positive cells in the hippocampus (obtained at autopsy from 74 subjects with no known neurological disorders). Immunohistochemical assay revealed that the immunopositive cells were GABAergic neurons and oligodendrocytes. They were first identified in the fetus at around 25 to 30 weeks and their number increased rapidly with advancing postconceptional age to reach maximal at the perinatal stage and in early postnatal life; it then decreased to the adult level by 10 years old. These results suggest that HCNP-related antigen may play important roles in the development and/or differentiation of the human hippocampus.

KW - Aging

KW - Development

KW - HCNP

KW - Hippocampal cholinergic neurostimulating peptide

KW - Human hippocampus

KW - Immunohistochemistry

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Age-dependent changes in HCNP-related antigen expression in the human hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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