Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa

James C.M. Brust; N. Sarita Shah; Theo L. Van Der Merwe; Sheila Bamber; Yuming Ning; Moonseong Heo; Anthony P. Moll; Marian Loveday; Umesh G. Lalloo; Gerald H. Friedland; Neel R. Gandhi

doi:10.1097/QAI.0b013e31828175ed

Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa

James C.M. Brust, N. Sarita Shah, Theo L. Van Der Merwe, Sheila Bamber, Yuming Ning, Moonseong Heo, Anthony P. Moll, Marian Loveday, Umesh G. Lalloo, Gerald H. Friedland, Neel R. Gandhi

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a homebased care setting.

Original language	English (US)
Pages (from-to)	436-440
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	62
Issue number	4
DOIs	https://doi.org/10.1097/QAI.0b013e31828175ed
State	Published - Apr 1 2013

Keywords

Adverse events
HIV
Multidrug-resistant tuberculosis
Resource-limited settings
Side effects

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAI.0b013e31828175ed

Cite this

Brust, J. C. M., Shah, N. S., Van Der Merwe, T. L., Bamber, S., Ning, Y., Heo, M., Moll, A. P., Loveday, M., Lalloo, U. G., Friedland, G. H., & Gandhi, N. R. (2013). Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa. Journal of Acquired Immune Deficiency Syndromes, 62(4), 436-440. https://doi.org/10.1097/QAI.0b013e31828175ed

Brust, JCM, Shah, NS, Van Der Merwe, TL, Bamber, S, Ning, Y, Heo, M, Moll, AP, Loveday, M, Lalloo, UG, Friedland, GH & Gandhi, NR 2013, 'Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa', Journal of Acquired Immune Deficiency Syndromes, vol. 62, no. 4, pp. 436-440. https://doi.org/10.1097/QAI.0b013e31828175ed

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Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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