Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa

James C.M. Brust, N. Sarita Shah, Theo L. Van Der Merwe, Sheila Bamber, Yuming Ning, Moonseong Heo, Anthony P. Moll, Marian Loveday, Umesh G. Lalloo, Gerald H. Friedland, Neel R. Gandhi

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a homebased care setting.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume62
Issue number4
DOIs
StatePublished - Apr 1 2013

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Keywords

  • Adverse events
  • HIV
  • Multidrug-resistant tuberculosis
  • Resource-limited settings
  • Side effects

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Brust, J. C. M., Shah, N. S., Van Der Merwe, T. L., Bamber, S., Ning, Y., Heo, M., Moll, A. P., Loveday, M., Lalloo, U. G., Friedland, G. H., & Gandhi, N. R. (2013). Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa. Journal of Acquired Immune Deficiency Syndromes, 62(4), 436-440. https://doi.org/10.1097/QAI.0b013e31828175ed