Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa

James C.M. Brust, N. Sarita Shah, Theo L. Van Der Merwe, Sheila Bamber, Yuming Ning, Moonseong Heo, Anthony P. Moll, Marian Loveday, Umesh G. Lalloo, Gerald H. Friedland, Neel R. Gandhi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a homebased care setting.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume62
Issue number4
DOIs
StatePublished - Apr 1 2013

Fingerprint

Multidrug-Resistant Tuberculosis
South Africa
HIV
Therapeutics
Hypothyroidism
Psychotic Disorders
Safety

Keywords

  • Adverse events
  • HIV
  • Multidrug-resistant tuberculosis
  • Resource-limited settings
  • Side effects

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa. / Brust, James C.M.; Shah, N. Sarita; Van Der Merwe, Theo L.; Bamber, Sheila; Ning, Yuming; Heo, Moonseong; Moll, Anthony P.; Loveday, Marian; Lalloo, Umesh G.; Friedland, Gerald H.; Gandhi, Neel R.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 62, No. 4, 01.04.2013, p. 436-440.

Research output: Contribution to journalArticle

Brust, JCM, Shah, NS, Van Der Merwe, TL, Bamber, S, Ning, Y, Heo, M, Moll, AP, Loveday, M, Lalloo, UG, Friedland, GH & Gandhi, NR 2013, 'Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa', Journal of Acquired Immune Deficiency Syndromes, vol. 62, no. 4, pp. 436-440. https://doi.org/10.1097/QAI.0b013e31828175ed
Brust, James C.M. ; Shah, N. Sarita ; Van Der Merwe, Theo L. ; Bamber, Sheila ; Ning, Yuming ; Heo, Moonseong ; Moll, Anthony P. ; Loveday, Marian ; Lalloo, Umesh G. ; Friedland, Gerald H. ; Gandhi, Neel R. / Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa. In: Journal of Acquired Immune Deficiency Syndromes. 2013 ; Vol. 62, No. 4. pp. 436-440.
@article{b2cd65a0b17245f5a4ace9c04201e0ee,
title = "Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa",
abstract = "Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81{\%}) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36{\%}) and psychosis (5{\%}). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a homebased care setting.",
keywords = "Adverse events, HIV, Multidrug-resistant tuberculosis, Resource-limited settings, Side effects",
author = "Brust, {James C.M.} and Shah, {N. Sarita} and {Van Der Merwe}, {Theo L.} and Sheila Bamber and Yuming Ning and Moonseong Heo and Moll, {Anthony P.} and Marian Loveday and Lalloo, {Umesh G.} and Friedland, {Gerald H.} and Gandhi, {Neel R.}",
year = "2013",
month = "4",
day = "1",
doi = "10.1097/QAI.0b013e31828175ed",
language = "English (US)",
volume = "62",
pages = "436--440",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa

AU - Brust, James C.M.

AU - Shah, N. Sarita

AU - Van Der Merwe, Theo L.

AU - Bamber, Sheila

AU - Ning, Yuming

AU - Heo, Moonseong

AU - Moll, Anthony P.

AU - Loveday, Marian

AU - Lalloo, Umesh G.

AU - Friedland, Gerald H.

AU - Gandhi, Neel R.

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a homebased care setting.

AB - Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a homebased care setting.

KW - Adverse events

KW - HIV

KW - Multidrug-resistant tuberculosis

KW - Resource-limited settings

KW - Side effects

UR - http://www.scopus.com/inward/record.url?scp=85027920247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027920247&partnerID=8YFLogxK

U2 - 10.1097/QAI.0b013e31828175ed

DO - 10.1097/QAI.0b013e31828175ed

M3 - Article

VL - 62

SP - 436

EP - 440

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 4

ER -