Adverse effects of drugs on the respiratory muscles

T. K. Aldrich, David J. Prezant

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Over 100 drugs can impair muscle function by (1) inhibiting neural drive, (2) causing peripheral neuropathy, (3) blocking neuromuscular junctions, (4) precipitating myasthenia gravis, or (5) producing myopathy. The best-known and most serious effects of drugs on respiratory muscle are sedative-associated respiratory failure, muscle relaxant-associated respiratory muscle paralysis, vaccine-associated Guillain-Barre syndrome, and antibiotic-associated potentiation of neuromuscular blockade. There are a number of other drug-induced neuropathies and myopathies, many of which can effect respiratory muscles, particularly the diaphragm. This article reviews what is known about the effects of drugs on respiratory myoneural function and what can be inferred from studies on other striated muscles.

Original languageEnglish (US)
Pages (from-to)177-189
Number of pages13
JournalClinics in Chest Medicine
Volume11
Issue number1
StatePublished - 1990
Externally publishedYes

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Respiratory Muscles
Muscular Diseases
Pharmaceutical Preparations
Respiratory Paralysis
Neuromuscular Blockade
Guillain-Barre Syndrome
Striated Muscle
Neuromuscular Junction
Myasthenia Gravis
Peripheral Nervous System Diseases
Diaphragm
Hypnotics and Sedatives
Respiratory Insufficiency
Vaccines
Anti-Bacterial Agents
Muscles

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Adverse effects of drugs on the respiratory muscles. / Aldrich, T. K.; Prezant, David J.

In: Clinics in Chest Medicine, Vol. 11, No. 1, 1990, p. 177-189.

Research output: Contribution to journalArticle

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