TY - JOUR
T1 - Advances in therapy for pediatric sarcomas
AU - Weiss, Aaron
AU - Gill, Jonathan
AU - Goldberg, John
AU - Lagmay, Joanne
AU - Spraker-Perlman, Holly
AU - Venkatramani, Rajkumar
AU - Reed, Damon
PY - 2014/8
Y1 - 2014/8
N2 - Pediatric sarcomas are relatively rare malignancies individually. As a group they are typically approached with combination chemotherapies in addition to local control. Fortunately, these malignancies have been approached through careful clinical trial collaboration to define risk groups and appropriately deliver local control measures and systemic therapies. Although local disease is typically approached with curative intent, therapy typically lasts over 6 months and has significant associated morbidities. It is more difficult to cure metastatic disease or induce sustained remissions. In this article, we discuss recent advances in the understanding of the disease process and highlight recent and future cooperative group trials in osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, nonrhabdomyosarcoma soft tissue sarcomas, and desmoid tumor as well as discuss promising therapeutic approaches such as epigenetics and immunotherapy.
AB - Pediatric sarcomas are relatively rare malignancies individually. As a group they are typically approached with combination chemotherapies in addition to local control. Fortunately, these malignancies have been approached through careful clinical trial collaboration to define risk groups and appropriately deliver local control measures and systemic therapies. Although local disease is typically approached with curative intent, therapy typically lasts over 6 months and has significant associated morbidities. It is more difficult to cure metastatic disease or induce sustained remissions. In this article, we discuss recent advances in the understanding of the disease process and highlight recent and future cooperative group trials in osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, nonrhabdomyosarcoma soft tissue sarcomas, and desmoid tumor as well as discuss promising therapeutic approaches such as epigenetics and immunotherapy.
KW - Oncology
KW - Pediatric sarcomas
KW - Rare malignancies
KW - Sarcomas
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=84901732194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901732194&partnerID=8YFLogxK
U2 - 10.1007/s11912-014-0395-z
DO - 10.1007/s11912-014-0395-z
M3 - Article
C2 - 24894064
AN - SCOPUS:84901732194
SN - 1523-3790
VL - 16
JO - Current oncology reports
JF - Current oncology reports
IS - 8
M1 - 395
ER -