Advances in the pathogenesis of adhesion development: The role of oxidative stress

Awoniyi O. Awonuga, Jimmy Belotte, Suleiman Abuanzeh, Nicole M. Fletcher, Michael P. Diamond, Ghassan M. Saed

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Over the past several years, there has been increasing recognition that pathogenesis of adhesion development includes significant contributions of hypoxia induced at the site of surgery, the resulting oxidative stress, and the subsequent free radical production. Mitochondrial dysfunction generated by surgically induced tissue hypoxia and inflammation can lead to the production of reactive oxygen and nitrogen species as well as antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase which when optimal have the potential to abrogate mitochondrial dysfunction and oxidative stress, preventing the cascade of events leading to the development of adhesions in injured peritoneum. There is a significant cross talk between the several processes leading to whether or not adhesions would eventually develop. Several of these processes present avenues for the development of measures that can help in abrogating adhesion formation or reformation after intraabdominal surgery.

Original languageEnglish (US)
Pages (from-to)823-836
Number of pages14
JournalReproductive Sciences
Volume21
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • adhesion markers
  • hypoxia
  • oxidative stress
  • postoperative adhesions

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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