Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy

Angela Wang Ilaltdinov, Yubao Gong, Daniel J. Leong, Konrad I. Gruson, Deyou Zheng, David T. Fung, Li Sun, Hui B. Sun

Research output: Contribution to journalReview articlepeer-review

Abstract

Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments for tendinopathy. The review also highlights recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer-sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1490
Issue number1
DOIs
StatePublished - Apr 1 2021

Keywords

  • exosomes
  • extracellular vesicles
  • gene therapy
  • lncRNA
  • miRNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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