Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy

Angela Wang Ilaltdinov; Yubao Gong; Daniel J. Leong; Konrad I. Gruson; Deyou Zheng; David T. Fung; Li Sun; Hui B. Sun

doi:10.1111/nyas.14382

Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy

Angela Wang Ilaltdinov, Yubao Gong, Daniel J. Leong, Konrad I. Gruson, Deyou Zheng, David T. Fung, Li Sun, Hui B. Sun

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments for tendinopathy. The review also highlights recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer-sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.

Original language	English (US)
Pages (from-to)	3-12
Number of pages	10
Journal	Annals of the New York Academy of Sciences
Volume	1490
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14382
State	Published - Feb 18 2021

Keywords

exosomes
extracellular vesicles
gene therapy
lncRNA
miRNA

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/nyas.14382

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title = "Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy",

abstract = "Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments for tendinopathy. The review also highlights recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer-sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.",

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AU - Ilaltdinov, Angela Wang

AU - Gong, Yubao

AU - Leong, Daniel J.

AU - Gruson, Konrad I.

AU - Zheng, Deyou

AU - Fung, David T.

AU - Sun, Li

AU - Sun, Hui B.

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N2 - Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments for tendinopathy. The review also highlights recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer-sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.

AB - Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments for tendinopathy. The review also highlights recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer-sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.

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Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy

Abstract

Keywords

ASJC Scopus subject areas

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