TY - CHAP
T1 - Advances in Imaging of Animal Models of Chagas Disease
AU - Jelicks, Linda A.
AU - Tanowitz, Herbert B.
N1 - Funding Information:
This study was supported by grants from the United States National Institutes of Health AI-062730 and CA-123334 (L. A. J.) and AI-076248 (H. B. T.).
PY - 2011
Y1 - 2011
N2 - Since serial studies of patients are limited, researchers interested in Chagas disease have relied on animal models of Trypanosoma cruzi infection to explore many aspects of this important human disease. These studies have been important for evaluation of the immunology, pathology, physiology and other aspects of pathogenesis. While larger animals have been employed, mice have remained the most favoured animal model, as they recapitulate many aspects of the human disease, are easy to manipulate genetically and are amenable to study by small animal imaging technologies. Further, developments in non-invasive imaging technologies have permitted the study of the same animal over an extended period of time by multiple imaging modalities, thus permitting the study of the transition from acute infection through the chronic stage and during therapeutic regimens.
AB - Since serial studies of patients are limited, researchers interested in Chagas disease have relied on animal models of Trypanosoma cruzi infection to explore many aspects of this important human disease. These studies have been important for evaluation of the immunology, pathology, physiology and other aspects of pathogenesis. While larger animals have been employed, mice have remained the most favoured animal model, as they recapitulate many aspects of the human disease, are easy to manipulate genetically and are amenable to study by small animal imaging technologies. Further, developments in non-invasive imaging technologies have permitted the study of the same animal over an extended period of time by multiple imaging modalities, thus permitting the study of the transition from acute infection through the chronic stage and during therapeutic regimens.
KW - (MRI), MicroPET, Echocardiography, Megasyndromes
KW - Chagas disease
KW - Chagasic cardiomyopathy
KW - Electrocardiography (ECG)
KW - Magnetic resonance imaging
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=79961012880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961012880&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-385863-4.00009-5
DO - 10.1016/B978-0-12-385863-4.00009-5
M3 - Chapter
AN - SCOPUS:79961012880
T3 - Advances in Parasitology
SP - 193
EP - 208
BT - Advances in Parasitology
PB - Academic Press
ER -