Advances in Imaging of Animal Models of Chagas Disease

Linda A. Jelicks, Herbert B. Tanowitz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Since serial studies of patients are limited, researchers interested in Chagas disease have relied on animal models of Trypanosoma cruzi infection to explore many aspects of this important human disease. These studies have been important for evaluation of the immunology, pathology, physiology and other aspects of pathogenesis. While larger animals have been employed, mice have remained the most favoured animal model, as they recapitulate many aspects of the human disease, are easy to manipulate genetically and are amenable to study by small animal imaging technologies. Further, developments in non-invasive imaging technologies have permitted the study of the same animal over an extended period of time by multiple imaging modalities, thus permitting the study of the transition from acute infection through the chronic stage and during therapeutic regimens.

Original languageEnglish (US)
Pages (from-to)193-208
Number of pages16
JournalAdvances in Parasitology
Volume75
DOIs
StatePublished - 2011

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Chagas Disease
Animal Models
Technology
Trypanosoma cruzi
Infection
Allergy and Immunology
Research Personnel
Pathology
Therapeutics

Keywords

  • (MRI), MicroPET, Echocardiography, Megasyndromes
  • Chagas disease
  • Chagasic cardiomyopathy
  • Electrocardiography (ECG)
  • Magnetic resonance imaging
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Parasitology

Cite this

Advances in Imaging of Animal Models of Chagas Disease. / Jelicks, Linda A.; Tanowitz, Herbert B.

In: Advances in Parasitology, Vol. 75, 2011, p. 193-208.

Research output: Contribution to journalArticle

Jelicks, Linda A. ; Tanowitz, Herbert B. / Advances in Imaging of Animal Models of Chagas Disease. In: Advances in Parasitology. 2011 ; Vol. 75. pp. 193-208.
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