Advances in epigenetics and epigenomics for neurodegenerative diseases

Irfan A. Qureshi, Mark F. Mehler

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

In the post-genomic era, epigenetic factors - literally those that are "over" or "above" genetic ones and responsible for controlling the expression and function of genes - have emerged as important mediators of development and aging; gene-gene and gene-environmental interactions; and the pathophysiology of complex disease states. Here, we provide a brief overview of the major epigenetic mechanisms (ie, DNA methylation, histone modifications and chromatin remodeling, and non-coding RNA regulation). We highlight the nearly ubiquitous profiles of epigenetic dysregulation that have been found in Alzheimer's and other neurodegenerative diseases.We also reviewinnovativemethods and technologies that enable the characterization of individual epigenetic modifications and more widespread epigenomic states at high resolution. We conclude that, together with complementary genetic, genomic, and related approaches, interrogating epigenetic and epigenomic profiles in neurodegenerative diseases represent important and increasingly practical strategies for advancing our understanding of and the diagnosis and treatment of these disorders.

Original languageEnglish (US)
Pages (from-to)464-473
Number of pages10
JournalCurrent Neurology and Neuroscience Reports
Volume11
Issue number5
DOIs
StatePublished - Oct 2011

Fingerprint

Epigenomics
Neurodegenerative Diseases
Histone Code
Genes
Untranslated RNA
Chromatin Assembly and Disassembly
DNA Methylation
Technology
Gene Expression

Keywords

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Chromatin
  • DNA methylation
  • Epigenetics
  • Epigenomics
  • Histone modification
  • Huntington's disease
  • Neurodegenerative disease
  • Next generation sequencing
  • Non-coding RNA
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Advances in epigenetics and epigenomics for neurodegenerative diseases. / Qureshi, Irfan A.; Mehler, Mark F.

In: Current Neurology and Neuroscience Reports, Vol. 11, No. 5, 10.2011, p. 464-473.

Research output: Contribution to journalArticle

@article{a5d7a56cc7894fe9a362bc1efe2eb34f,
title = "Advances in epigenetics and epigenomics for neurodegenerative diseases",
abstract = "In the post-genomic era, epigenetic factors - literally those that are {"}over{"} or {"}above{"} genetic ones and responsible for controlling the expression and function of genes - have emerged as important mediators of development and aging; gene-gene and gene-environmental interactions; and the pathophysiology of complex disease states. Here, we provide a brief overview of the major epigenetic mechanisms (ie, DNA methylation, histone modifications and chromatin remodeling, and non-coding RNA regulation). We highlight the nearly ubiquitous profiles of epigenetic dysregulation that have been found in Alzheimer's and other neurodegenerative diseases.We also reviewinnovativemethods and technologies that enable the characterization of individual epigenetic modifications and more widespread epigenomic states at high resolution. We conclude that, together with complementary genetic, genomic, and related approaches, interrogating epigenetic and epigenomic profiles in neurodegenerative diseases represent important and increasingly practical strategies for advancing our understanding of and the diagnosis and treatment of these disorders.",
keywords = "Alzheimer's disease, Amyotrophic lateral sclerosis, Chromatin, DNA methylation, Epigenetics, Epigenomics, Histone modification, Huntington's disease, Neurodegenerative disease, Next generation sequencing, Non-coding RNA, Parkinson's disease",
author = "Qureshi, {Irfan A.} and Mehler, {Mark F.}",
year = "2011",
month = "10",
doi = "10.1007/s11910-011-0210-2",
language = "English (US)",
volume = "11",
pages = "464--473",
journal = "Current Neurology and Neuroscience Reports",
issn = "1528-4042",
publisher = "Current Medicine Group",
number = "5",

}

TY - JOUR

T1 - Advances in epigenetics and epigenomics for neurodegenerative diseases

AU - Qureshi, Irfan A.

AU - Mehler, Mark F.

PY - 2011/10

Y1 - 2011/10

N2 - In the post-genomic era, epigenetic factors - literally those that are "over" or "above" genetic ones and responsible for controlling the expression and function of genes - have emerged as important mediators of development and aging; gene-gene and gene-environmental interactions; and the pathophysiology of complex disease states. Here, we provide a brief overview of the major epigenetic mechanisms (ie, DNA methylation, histone modifications and chromatin remodeling, and non-coding RNA regulation). We highlight the nearly ubiquitous profiles of epigenetic dysregulation that have been found in Alzheimer's and other neurodegenerative diseases.We also reviewinnovativemethods and technologies that enable the characterization of individual epigenetic modifications and more widespread epigenomic states at high resolution. We conclude that, together with complementary genetic, genomic, and related approaches, interrogating epigenetic and epigenomic profiles in neurodegenerative diseases represent important and increasingly practical strategies for advancing our understanding of and the diagnosis and treatment of these disorders.

AB - In the post-genomic era, epigenetic factors - literally those that are "over" or "above" genetic ones and responsible for controlling the expression and function of genes - have emerged as important mediators of development and aging; gene-gene and gene-environmental interactions; and the pathophysiology of complex disease states. Here, we provide a brief overview of the major epigenetic mechanisms (ie, DNA methylation, histone modifications and chromatin remodeling, and non-coding RNA regulation). We highlight the nearly ubiquitous profiles of epigenetic dysregulation that have been found in Alzheimer's and other neurodegenerative diseases.We also reviewinnovativemethods and technologies that enable the characterization of individual epigenetic modifications and more widespread epigenomic states at high resolution. We conclude that, together with complementary genetic, genomic, and related approaches, interrogating epigenetic and epigenomic profiles in neurodegenerative diseases represent important and increasingly practical strategies for advancing our understanding of and the diagnosis and treatment of these disorders.

KW - Alzheimer's disease

KW - Amyotrophic lateral sclerosis

KW - Chromatin

KW - DNA methylation

KW - Epigenetics

KW - Epigenomics

KW - Histone modification

KW - Huntington's disease

KW - Neurodegenerative disease

KW - Next generation sequencing

KW - Non-coding RNA

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=81055157117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81055157117&partnerID=8YFLogxK

U2 - 10.1007/s11910-011-0210-2

DO - 10.1007/s11910-011-0210-2

M3 - Article

C2 - 21671162

AN - SCOPUS:81055157117

VL - 11

SP - 464

EP - 473

JO - Current Neurology and Neuroscience Reports

JF - Current Neurology and Neuroscience Reports

SN - 1528-4042

IS - 5

ER -