TY - JOUR
T1 - Advances in autism genetics
T2 - On the threshold of a new neurobiology
AU - Abrahams, Brett S.
AU - Geschwind, Daniel H.
N1 - Funding Information:
We gratefully acknowledge the families who have made these studies possible — along with the vision and leadership of AGRE and Autism Speaks. We are similarly indebted to the investigators whose work drives this field forward, many of whom we were unable to cite owing to space limitations. Thanks also to E. Herman, R. Mar-Heyming, B. Fogel and other members of the Geschwind laboratory for discussions. We also thank the anonymous reviewers. Work in the Geschwind laboratory is supported by funding from Autism Speaks, the Cure Autism Now Foundation, the National Institue of Mental Health (STAART - U54 MH68172; ACE - P50 HD055784; AGRE R01 MH64547; Asymmetry R37 MH60233) and the Tourette Syndrome Association.
PY - 2008/5
Y1 - 2008/5
N2 - Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.
AB - Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.
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U2 - 10.1038/nrg2346
DO - 10.1038/nrg2346
M3 - Review article
C2 - 18414403
AN - SCOPUS:42349095075
SN - 1471-0056
VL - 9
SP - 341
EP - 355
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 5
ER -