TY - JOUR
T1 - Advances in autism genetics
T2 - On the threshold of a new neurobiology
AU - Abrahams, Brett S.
AU - Geschwind, Daniel H.
PY - 2008/5
Y1 - 2008/5
N2 - Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.
AB - Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.
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U2 - 10.1038/nrg2346
DO - 10.1038/nrg2346
M3 - Review article
C2 - 18414403
AN - SCOPUS:42349095075
VL - 9
SP - 341
EP - 355
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
SN - 1471-0056
IS - 5
ER -