Advanced ovarian dysgerminoma with cure of tumor persistent in meninges

Christopher J. Jolles; Sharon Karayianis; David Smotkin; Julian E. DeLia

doi:10.1016/0090-8258(89)90535-0

Advanced ovarian dysgerminoma with cure of tumor persistent in meninges

Christopher J. Jolles, Sharon Karayianis, David Smotkin, Julian E. DeLia

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Isolated meningeal recurrence of ovarian cancer is uncommon. It is generally assumed that such cases are not accompanied by prolonged survival. We report the cure of a patient with advanced ovarian dysgerminoma who developed febrile carcinomatous meningitis 2 weeks after receiving her fifth course of combination chemotherapy (5 months after initiation of chemotherapy). No parenchymal brain disease was identified. The persistence of disease in the leptomeninges is related to the ability of the blood-brain barrier to exclude chemotherapeutic agents. The patient responded to craniospinal radiation and remains free of disease 2 years after completion of treatment.

Original language	English (US)
Pages (from-to)	389-391
Number of pages	3
Journal	Gynecologic Oncology
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/0090-8258(89)90535-0
State	Published - Jun 1989
Externally published	Yes

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0090-8258(89)90535-0

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title = "Advanced ovarian dysgerminoma with cure of tumor persistent in meninges",

abstract = "Isolated meningeal recurrence of ovarian cancer is uncommon. It is generally assumed that such cases are not accompanied by prolonged survival. We report the cure of a patient with advanced ovarian dysgerminoma who developed febrile carcinomatous meningitis 2 weeks after receiving her fifth course of combination chemotherapy (5 months after initiation of chemotherapy). No parenchymal brain disease was identified. The persistence of disease in the leptomeninges is related to the ability of the blood-brain barrier to exclude chemotherapeutic agents. The patient responded to craniospinal radiation and remains free of disease 2 years after completion of treatment.",

author = "Jolles, {Christopher J.} and Sharon Karayianis and David Smotkin and DeLia, {Julian E.}",

year = "1989",

month = jun,

doi = "10.1016/0090-8258(89)90535-0",

language = "English (US)",

volume = "33",

pages = "389--391",

journal = "Gynecologic Oncology",

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T1 - Advanced ovarian dysgerminoma with cure of tumor persistent in meninges

AU - Jolles, Christopher J.

AU - Karayianis, Sharon

AU - Smotkin, David

AU - DeLia, Julian E.

PY - 1989/6

Y1 - 1989/6

N2 - Isolated meningeal recurrence of ovarian cancer is uncommon. It is generally assumed that such cases are not accompanied by prolonged survival. We report the cure of a patient with advanced ovarian dysgerminoma who developed febrile carcinomatous meningitis 2 weeks after receiving her fifth course of combination chemotherapy (5 months after initiation of chemotherapy). No parenchymal brain disease was identified. The persistence of disease in the leptomeninges is related to the ability of the blood-brain barrier to exclude chemotherapeutic agents. The patient responded to craniospinal radiation and remains free of disease 2 years after completion of treatment.

AB - Isolated meningeal recurrence of ovarian cancer is uncommon. It is generally assumed that such cases are not accompanied by prolonged survival. We report the cure of a patient with advanced ovarian dysgerminoma who developed febrile carcinomatous meningitis 2 weeks after receiving her fifth course of combination chemotherapy (5 months after initiation of chemotherapy). No parenchymal brain disease was identified. The persistence of disease in the leptomeninges is related to the ability of the blood-brain barrier to exclude chemotherapeutic agents. The patient responded to craniospinal radiation and remains free of disease 2 years after completion of treatment.

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AN - SCOPUS:0024374931

SN - 0090-8258

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SP - 389

EP - 391

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 3

ER -

Advanced ovarian dysgerminoma with cure of tumor persistent in meninges

Abstract

ASJC Scopus subject areas

UN SDGs

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