Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

J. Tiago Goncalves, Simon T. Schafer, Fred H. Gage

Research output: Contribution to journalReview article

302 Scopus citations

Abstract

The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits. We also summarize the potential functions of these newborn neurons in the adult brain, their contribution to behavior, and their relevance to disease.

Original languageEnglish (US)
Pages (from-to)897-914
Number of pages18
JournalCell
Volume167
Issue number4
DOIs
StatePublished - Nov 3 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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