Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

J. Tiago Gonçalves; Simon T. Schafer; Fred H. Gage

doi:10.1016/j.cell.2016.10.021

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

J. Tiago Gonçalves, Simon T. Schafer, Fred H. Gage

Research output: Contribution to journal › Review article › peer-review

750 Scopus citations

Abstract

The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits. We also summarize the potential functions of these newborn neurons in the adult brain, their contribution to behavior, and their relevance to disease.

Original language	English (US)
Pages (from-to)	897-914
Number of pages	18
Journal	Cell
Volume	167
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2016.10.021
State	Published - Nov 3 2016
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2016.10.021

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abstract = "The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits. We also summarize the potential functions of these newborn neurons in the adult brain, their contribution to behavior, and their relevance to disease.",

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AB - The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits. We also summarize the potential functions of these newborn neurons in the adult brain, their contribution to behavior, and their relevance to disease.

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Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

Abstract

ASJC Scopus subject areas

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