Adult height in relation to risk of cancer in a cohort of Canadian women

Geoffrey C. Kabat, Moonseong Heo, Victor Kamensky, Anthony B. Miller, Thomas E. Rohan

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Although the influence of body mass index on cancer risk has been intensively investigated, few epidemiologic studies have examined the association of adult height with risk of cancer. We assessed the association of height with risk of all cancer and of 19 site-specific cancers in the Canadian National Breast Screening Study, a prospective cohort of nearly 90,000 women. Weight and height were measured at enrollment, and information on reproductive and medical history as well as lifestyle exposures was obtained by means of questionnaire. After exclusions, 5,679 incident invasive cancers were identified among 88,256 women. We used Cox proportional hazards model to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI) per 10 cm increase in height. All tests of statistical significance were two sided. All cancers combined and ten specific sites (colorectum, colon, premenopausal breast, postmenopausal breast, endometrium, ovary, kidney, thyroid, melanoma and leukemia) showed statistically significant positive associations with height. The HR for all cancers combined was 1.13 (95% CI: 1.08-1.18), and the magnitude of the associations for specific sites ranged from HR 1.11 (95% CI: 1.03-1.20) for postmenopausal breast cancer to HR 1.51 (95% CI: 1.27-1.80) for melanoma. Our study provides strong support for a positive association of adult height with risk of certain cancers. The underlying biological mechanisms are not clear but may differ by anatomic site.

Original languageEnglish (US)
Pages (from-to)1125-1132
Number of pages8
JournalInternational Journal of Cancer
Volume132
Issue number5
DOIs
StatePublished - Mar 1 2013

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Neoplasms
Confidence Intervals
Breast
Melanoma
Reproductive History
Endometrium
Proportional Hazards Models
Life Style
Epidemiologic Studies
Ovary
Thyroid Gland
Colon
Leukemia
Body Mass Index
Prospective Studies
Breast Neoplasms
Kidney
Weights and Measures

Keywords

  • cancer incidence
  • cohort studies
  • height

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Adult height in relation to risk of cancer in a cohort of Canadian women. / Kabat, Geoffrey C.; Heo, Moonseong; Kamensky, Victor; Miller, Anthony B.; Rohan, Thomas E.

In: International Journal of Cancer, Vol. 132, No. 5, 01.03.2013, p. 1125-1132.

Research output: Contribution to journalArticle

Kabat, Geoffrey C. ; Heo, Moonseong ; Kamensky, Victor ; Miller, Anthony B. ; Rohan, Thomas E. / Adult height in relation to risk of cancer in a cohort of Canadian women. In: International Journal of Cancer. 2013 ; Vol. 132, No. 5. pp. 1125-1132.
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