Adreno-leukodystrophy: Similar Ultrastructural Changes in Adrenal Cortical and Schwann Cells

James M. Powers, Herbert H. Schaumburg

Research output: Contribution to journalArticle

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Abstract

Ultrastructural observations of an adrenal biopsy specimen from an 11-year-old boy with adreno-leukodystrophy showed that adrenocortical cells contained cytoplasmic accumulations of lamellar material. Each lamella consisted of two parallel, electron-dense 25 Angstrom leaflets separated by a variable 20 A to 70 A space. Rows of glycogen and a clear space often surrounded this material. Similar accumulations were also present in the Schwann cell cytoplasm of many of the myelinated nerve fibers in the adrenal capsule. These findings represent a possible morphologic link between the endocrine and nervous systems in this disease.

Original languageEnglish (US)
Pages (from-to)406-408
Number of pages3
JournalArchives of Neurology
Volume30
Issue number5
DOIs
StatePublished - May 1974

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ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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