TY - JOUR
T1 - Adreno-leukodystrophy
T2 - Similar Ultrastructural Changes in Adrenal Cortical and Schwann Cells
AU - Powers, James M.
AU - Schaumburg, Herbert H.
PY - 1974/5
Y1 - 1974/5
N2 - Ultrastructural observations of an adrenal biopsy specimen from an 11-year-old boy with adreno-leukodystrophy showed that adrenocortical cells contained cytoplasmic accumulations of lamellar material. Each lamella consisted of two parallel, electron-dense 25 Angstrom leaflets separated by a variable 20 A to 70 A space. Rows of glycogen and a clear space often surrounded this material. Similar accumulations were also present in the Schwann cell cytoplasm of many of the myelinated nerve fibers in the adrenal capsule. These findings represent a possible morphologic link between the endocrine and nervous systems in this disease.
AB - Ultrastructural observations of an adrenal biopsy specimen from an 11-year-old boy with adreno-leukodystrophy showed that adrenocortical cells contained cytoplasmic accumulations of lamellar material. Each lamella consisted of two parallel, electron-dense 25 Angstrom leaflets separated by a variable 20 A to 70 A space. Rows of glycogen and a clear space often surrounded this material. Similar accumulations were also present in the Schwann cell cytoplasm of many of the myelinated nerve fibers in the adrenal capsule. These findings represent a possible morphologic link between the endocrine and nervous systems in this disease.
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U2 - 10.1001/archneur.1974.00490350064011
DO - 10.1001/archneur.1974.00490350064011
M3 - Article
C2 - 4821786
AN - SCOPUS:0016138869
SN - 0003-9942
VL - 30
SP - 406
EP - 408
JO - Archives of Neurology
JF - Archives of Neurology
IS - 5
ER -