Adreno-leukodystrophy (Sex-Linked Schilder Disease): Ultrastructural Demonstration of Specific Cytoplasmic Inclusions in the Central Nervous System

Herbert H. Schaumburg, James M. Powers, Kinuko Suzuki, Cedric S. Raine

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

An ultrastructural study of the central nervous system of four male patients with adreno-leukodystrophy has been performed. Membrane-like cytoplasmic inclusions similar to those described in adrenal cortex, testis, and peripheral nerve were present in macrophages. These changes in widely scattered organs are probably the structural representation of a generalized metabolic disorder and are consistent with our previous hypothesis of a membrane-stability defect in these organs.

Original languageEnglish (US)
Pages (from-to)210-213
Number of pages4
JournalArchives of Neurology
Volume31
Issue number3
DOIs
StatePublished - Sep 1974

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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