TY - JOUR
T1 - Adreno-leukodystrophy (Sex-Linked Schilder Disease)
T2 - Ultrastructural Demonstration of Specific Cytoplasmic Inclusions in the Central Nervous System
AU - Schaumburg, Herbert H.
AU - Powers, James M.
AU - Suzuki, Kinuko
AU - Raine, Cedric S.
PY - 1974/9
Y1 - 1974/9
N2 - An ultrastructural study of the central nervous system of four male patients with adreno-leukodystrophy has been performed. Membrane-like cytoplasmic inclusions similar to those described in adrenal cortex, testis, and peripheral nerve were present in macrophages. These changes in widely scattered organs are probably the structural representation of a generalized metabolic disorder and are consistent with our previous hypothesis of a membrane-stability defect in these organs.
AB - An ultrastructural study of the central nervous system of four male patients with adreno-leukodystrophy has been performed. Membrane-like cytoplasmic inclusions similar to those described in adrenal cortex, testis, and peripheral nerve were present in macrophages. These changes in widely scattered organs are probably the structural representation of a generalized metabolic disorder and are consistent with our previous hypothesis of a membrane-stability defect in these organs.
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U2 - 10.1001/archneur.1974.00490390092013
DO - 10.1001/archneur.1974.00490390092013
M3 - Article
C2 - 4368379
AN - SCOPUS:0016204228
SN - 0003-9942
VL - 31
SP - 210
EP - 213
JO - Archives of Neurology
JF - Archives of Neurology
IS - 3
ER -