Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens

Rosa Weiler; Shulamit Cidon; Michael D. Gershon; Hadassah Tamir; Ruth Hogue-Angeletti; Hans Winkler

doi:10.1016/0014-5793(89)81595-9

Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens

Rosa Weiler, Shulamit Cidon, Michael D. Gershon, Hadassah Tamir, Ruth Hogue-Angeletti, Hans Winkler

Developmental & Molecular Biology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The presence of various antigens in two types of isolated endocrine vesicles (chromaffin granules and secretory vesicles of thyroid parafollicular cells) was investigated by immunoblotting. The twotypes of vesicles have three common secretory proteins: chromogranin A, chromogranin B and secretogranin II. Furthermore, six common membrane antigens were found: cytochrome b-561, carboxypeptidase H, glycoprotein II, glycoprotein III, synaptin/synaptophysin and SV 2. These results demonstrate that vesicles obtained from neural crest-derived endocrine cells not only share several common secretory peptides and proteins, but also have common properties as far as their membrane antigens are concerned.

Original language	English (US)
Pages (from-to)	457-459
Number of pages	3
Journal	FEBS Letters
Volume	257
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)81595-9
State	Published - Nov 6 1989

Keywords

Chromaffin granule
Chromogranin A
Chromogranin B
Cytochrome b-561
Parafollicular cell thyroid
Synaptin
Synaptophysin

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(89)81595-9

Cite this

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title = "Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens",

abstract = "The presence of various antigens in two types of isolated endocrine vesicles (chromaffin granules and secretory vesicles of thyroid parafollicular cells) was investigated by immunoblotting. The twotypes of vesicles have three common secretory proteins: chromogranin A, chromogranin B and secretogranin II. Furthermore, six common membrane antigens were found: cytochrome b-561, carboxypeptidase H, glycoprotein II, glycoprotein III, synaptin/synaptophysin and SV 2. These results demonstrate that vesicles obtained from neural crest-derived endocrine cells not only share several common secretory peptides and proteins, but also have common properties as far as their membrane antigens are concerned.",

keywords = "Chromaffin granule, Chromogranin A, Chromogranin B, Cytochrome b-561, Parafollicular cell thyroid, Synaptin, Synaptophysin",

author = "Rosa Weiler and Shulamit Cidon and Gershon, {Michael D.} and Hadassah Tamir and Ruth Hogue-Angeletti and Hans Winkler",

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T1 - Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens

AU - Weiler, Rosa

AU - Cidon, Shulamit

AU - Gershon, Michael D.

AU - Tamir, Hadassah

AU - Hogue-Angeletti, Ruth

AU - Winkler, Hans

PY - 1989/11/6

Y1 - 1989/11/6

N2 - The presence of various antigens in two types of isolated endocrine vesicles (chromaffin granules and secretory vesicles of thyroid parafollicular cells) was investigated by immunoblotting. The twotypes of vesicles have three common secretory proteins: chromogranin A, chromogranin B and secretogranin II. Furthermore, six common membrane antigens were found: cytochrome b-561, carboxypeptidase H, glycoprotein II, glycoprotein III, synaptin/synaptophysin and SV 2. These results demonstrate that vesicles obtained from neural crest-derived endocrine cells not only share several common secretory peptides and proteins, but also have common properties as far as their membrane antigens are concerned.

AB - The presence of various antigens in two types of isolated endocrine vesicles (chromaffin granules and secretory vesicles of thyroid parafollicular cells) was investigated by immunoblotting. The twotypes of vesicles have three common secretory proteins: chromogranin A, chromogranin B and secretogranin II. Furthermore, six common membrane antigens were found: cytochrome b-561, carboxypeptidase H, glycoprotein II, glycoprotein III, synaptin/synaptophysin and SV 2. These results demonstrate that vesicles obtained from neural crest-derived endocrine cells not only share several common secretory peptides and proteins, but also have common properties as far as their membrane antigens are concerned.

KW - Chromaffin granule

KW - Chromogranin A

KW - Chromogranin B

KW - Cytochrome b-561

KW - Parafollicular cell thyroid

KW - Synaptin

KW - Synaptophysin

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Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens

Abstract

Keywords

ASJC Scopus subject areas

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