Administered dose and tumor dose of bleomycin labeled with cobalt-57 in mice and men

D. Front, O. Israel, G. Iosilevsky, E. Even-Sapir, S. Ben-Haim, A. Frenkel, R. Ber, D. Milstein, G. M. Kolodny

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5 Scopus citations

Abstract

Tumor concentrations of the chemotherapeutic drug, bleomycin, labeled with cobalt-57 (Co-bleo) were compared in mouse tumor models and in human lung tumors using quantitative single-photon emission computed tomography. Drug concentrations in histologically similar human tumors showed marked variability for the same injected dose (ID). Small cell carcinomas showed concentrations between 1.09 and 8.85 %ID/cc x 10-3 while non-small cell lung tumors showed a concentration variation between 0.36 and 6.75 %ID/cc x 10-3. In contrast to the situation in human tumors, uptake in mouse tumors showed only slight variability in animals with the same tumor model. EMT-6 tumors in mice showed at 6 hr significantly higher uptake of Co-bleo (p < 0.001) and significantly higher tumor-to-lung ratio (p < 0.001) when compared to murine fibrosarcomas. The EMT-6 tumors in contrast to the fibrosarcomas responded to bleomycin treatment in a dose dependent manner. The results indicate that while in mice the tumor dose closely follows the administered dose, in humans, the tumor dose and the tumor-to-lung ratio in the individual patient cannot be predicted from the administered dose.

Original languageEnglish (US)
Pages (from-to)1784-1790
Number of pages7
JournalJournal of Nuclear Medicine
Volume31
Issue number11
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Front, D., Israel, O., Iosilevsky, G., Even-Sapir, E., Ben-Haim, S., Frenkel, A., Ber, R., Milstein, D., & Kolodny, G. M. (1990). Administered dose and tumor dose of bleomycin labeled with cobalt-57 in mice and men. Journal of Nuclear Medicine, 31(11), 1784-1790.