Adiposity and incident heart failure in older adults

The cardiovascular health study

Luc Djoussé, Traci M. Bartz, Joachim H. Ix, Susan J. Zieman, Joseph A. Delaney, Kenneth J. Mukamal, John S. Gottdiener, David S. Siscovick, Jorge Kizer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

While several studies have reported a positive association between overall adiposity and heart failure (HF) risk, limited and inconsistent data are available on the relation between central adiposity and incident HF in older adults. We sought to examine the association between waist circumference (WC) and incident HF and assess whether sex modifies the relation between WC and HF.Prospective study using data on 4,861 participants of the Cardiovascular Health Study (1989-2007). HF was adjudicated by a committee using information from medical records and medications. We used Cox proportional hazard models to compute hazard ratio (HR). The mean age was 73.0 years for men and 72.3 years for women; 42.5% were men and 15.3% were African Americans. WC was positively associated with an increased risk of HF: each standard deviation of WC was associated with a 14% increased risk of HF (95% CI: 3%-26%) in a multivariable model. There was not a statistically significant sex-by-WC interaction (P = 0.081). BMI was positively associated with incident HF (HR: 1.22 (95% CI: 1.15-1.29) per standard deviation increase of BMI); however, this association was attenuated and became nonstatistically significant upon additional adjustment for WC (HR: 1.09 (95% CI: 0.99-1.21)). In conclusion, a higher WC is associated with an increased risk of HF independent of BMI in community-living older men and women.

Original languageEnglish (US)
Pages (from-to)1936-1941
Number of pages6
JournalObesity
Volume20
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

Fingerprint

Adiposity
Waist Circumference
Heart Failure
Health
Proportional Hazards Models
African Americans
Medical Records
Prospective Studies

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Djoussé, L., Bartz, T. M., Ix, J. H., Zieman, S. J., Delaney, J. A., Mukamal, K. J., ... Kizer, J. (2012). Adiposity and incident heart failure in older adults: The cardiovascular health study. Obesity, 20(9), 1936-1941. https://doi.org/10.1038/oby.2011.320

Adiposity and incident heart failure in older adults : The cardiovascular health study. / Djoussé, Luc; Bartz, Traci M.; Ix, Joachim H.; Zieman, Susan J.; Delaney, Joseph A.; Mukamal, Kenneth J.; Gottdiener, John S.; Siscovick, David S.; Kizer, Jorge.

In: Obesity, Vol. 20, No. 9, 09.2012, p. 1936-1941.

Research output: Contribution to journalArticle

Djoussé, L, Bartz, TM, Ix, JH, Zieman, SJ, Delaney, JA, Mukamal, KJ, Gottdiener, JS, Siscovick, DS & Kizer, J 2012, 'Adiposity and incident heart failure in older adults: The cardiovascular health study', Obesity, vol. 20, no. 9, pp. 1936-1941. https://doi.org/10.1038/oby.2011.320
Djoussé L, Bartz TM, Ix JH, Zieman SJ, Delaney JA, Mukamal KJ et al. Adiposity and incident heart failure in older adults: The cardiovascular health study. Obesity. 2012 Sep;20(9):1936-1941. https://doi.org/10.1038/oby.2011.320
Djoussé, Luc ; Bartz, Traci M. ; Ix, Joachim H. ; Zieman, Susan J. ; Delaney, Joseph A. ; Mukamal, Kenneth J. ; Gottdiener, John S. ; Siscovick, David S. ; Kizer, Jorge. / Adiposity and incident heart failure in older adults : The cardiovascular health study. In: Obesity. 2012 ; Vol. 20, No. 9. pp. 1936-1941.
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