Adiposity and cognitive decline in the cardiovascular health study

José A. Luchsinger, Mary L. Biggs, Jorge Kizer, Joshua Barzilay, Annette Fitzpatrick, Anne Newman, William T. Longstreth, Oscar Lopez, David Siscovick, Lewis Kuller

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Studies relating adiposity to cognition in the elderly show conflicting results, which may be explained by the choice of adiposity measures. Thus, we studied the longitudinal associations of different adiposity measures, fat mass by bioelectrical impedance analysis, body mass index (BMI) and waist circumference (WC), with cognitive performance in the Cardiovascular Health Study. Methods: Cognitive performance was assessed with the modified Mini-Mental State Examination, the Digit Symbol Substitution Test, and a composite of both. We used linear mixed models to estimate rates of change in cognitive function scores associated with adiposity measured at baseline. Results: The final sample was comprised of 2,681 women (57.9%) and 1,949 men (42.1%) aged 73 ± 5.2 and 73.9 ± 5.6 years, respectively. Adiposity was associated with slower cognitive decline in most analyses. Results were similar for fat mass, BMI and WC. Higher fat-free mass was also related to slower cognitive decline. Results were similar in analyses excluding persons with cancer, smokers, and persons with short follow-up, poor self-reported health, or persons with cardiovascular disease. Conclusions: Higher adiposity and higher fat-free mass in the elderly was related to better cognitive performance. This finding was not explained by confounding by preexisting conditions.

Original languageEnglish (US)
Pages (from-to)274-281
Number of pages8
JournalNeuroepidemiology
Volume40
Issue number4
DOIs
StatePublished - May 2013

Fingerprint

Adiposity
Health
Fats
Waist Circumference
Cognition
Body Mass Index
Preexisting Condition Coverage
Electric Impedance
Cognitive Dysfunction
Linear Models
Cardiovascular Diseases
Neoplasms

Keywords

  • Adiposity
  • Bioelectrical impedance
  • Body mass index
  • Cognition
  • Fat mass
  • Waist circumference

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Luchsinger, J. A., Biggs, M. L., Kizer, J., Barzilay, J., Fitzpatrick, A., Newman, A., ... Kuller, L. (2013). Adiposity and cognitive decline in the cardiovascular health study. Neuroepidemiology, 40(4), 274-281. https://doi.org/10.1159/000345136

Adiposity and cognitive decline in the cardiovascular health study. / Luchsinger, José A.; Biggs, Mary L.; Kizer, Jorge; Barzilay, Joshua; Fitzpatrick, Annette; Newman, Anne; Longstreth, William T.; Lopez, Oscar; Siscovick, David; Kuller, Lewis.

In: Neuroepidemiology, Vol. 40, No. 4, 05.2013, p. 274-281.

Research output: Contribution to journalArticle

Luchsinger, JA, Biggs, ML, Kizer, J, Barzilay, J, Fitzpatrick, A, Newman, A, Longstreth, WT, Lopez, O, Siscovick, D & Kuller, L 2013, 'Adiposity and cognitive decline in the cardiovascular health study', Neuroepidemiology, vol. 40, no. 4, pp. 274-281. https://doi.org/10.1159/000345136
Luchsinger JA, Biggs ML, Kizer J, Barzilay J, Fitzpatrick A, Newman A et al. Adiposity and cognitive decline in the cardiovascular health study. Neuroepidemiology. 2013 May;40(4):274-281. https://doi.org/10.1159/000345136
Luchsinger, José A. ; Biggs, Mary L. ; Kizer, Jorge ; Barzilay, Joshua ; Fitzpatrick, Annette ; Newman, Anne ; Longstreth, William T. ; Lopez, Oscar ; Siscovick, David ; Kuller, Lewis. / Adiposity and cognitive decline in the cardiovascular health study. In: Neuroepidemiology. 2013 ; Vol. 40, No. 4. pp. 274-281.
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