Adipose tissue, diabetes and chagas disease

Herbert B. Tanowitz, Linda A. Jelicks, Fabiana S. Machado, Lisia Esper, Xiaohua Qi, Mahalia S. Desruisseaux, Streamson C. Chua, Philipp E. Scherer, Fnu Nagajyothi

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Abstract

Adipose tissue is the largest endocrine organ in the body and is composed primarily of adipocytes (fat cells) but also contains fibroblasts, endothelial cells, smooth muscle cells, macrophages and lymphocytes. Adipose tissue and the adipocyte are important in the regulation of energy metabolism and of the immune response. Adipocytes also synthesize adipokines such as adiponectin which is important in the regulation of insulin sensitivity and inflammation. Infection of mice with Trypanosoma cruzi results in an upregulation of inflammation in adipose tissue that begins during the acute phase of infection and persists into the chronic phase. The adipocyte is both a target of infection and a reservoir for the parasite during the chronic phase from which recrudescence of the infection may occur during periods of immunosuppression.

Original languageEnglish (US)
Title of host publicationAdvances in Parasitology
PublisherAcademic Press
Pages235-250
Number of pages16
DOIs
StatePublished - 2011

Publication series

NameAdvances in Parasitology
Volume76
ISSN (Print)0065-308X

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Keywords

  • Adipocyte
  • Adipokines
  • Adiponectin
  • Adipose tissue
  • Chagas disease
  • Chemokines
  • Cytokines
  • Diabetes
  • Fat cell
  • Inflammation
  • Macrophage
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Parasitology

Cite this

Tanowitz, H. B., Jelicks, L. A., Machado, F. S., Esper, L., Qi, X., Desruisseaux, M. S., Chua, S. C., Scherer, P. E., & Nagajyothi, F. (2011). Adipose tissue, diabetes and chagas disease. In Advances in Parasitology (pp. 235-250). (Advances in Parasitology; Vol. 76). Academic Press. https://doi.org/10.1016/B978-0-12-385895-5.00010-4