@inbook{d1ad64ad3f824a7e8e16ce8ad625cab9,
title = "Adipose tissue, diabetes and chagas disease",
abstract = "Adipose tissue is the largest endocrine organ in the body and is composed primarily of adipocytes (fat cells) but also contains fibroblasts, endothelial cells, smooth muscle cells, macrophages and lymphocytes. Adipose tissue and the adipocyte are important in the regulation of energy metabolism and of the immune response. Adipocytes also synthesize adipokines such as adiponectin which is important in the regulation of insulin sensitivity and inflammation. Infection of mice with Trypanosoma cruzi results in an upregulation of inflammation in adipose tissue that begins during the acute phase of infection and persists into the chronic phase. The adipocyte is both a target of infection and a reservoir for the parasite during the chronic phase from which recrudescence of the infection may occur during periods of immunosuppression.",
keywords = "Adipocyte, Adipokines, Adiponectin, Adipose tissue, Chagas disease, Chemokines, Cytokines, Diabetes, Fat cell, Inflammation, Macrophage, Trypanosoma cruzi",
author = "Tanowitz, {Herbert B.} and Jelicks, {Linda A.} and Machado, {Fabiana S.} and Lisia Esper and Xiaohua Qi and Desruisseaux, {Mahalia S.} and Chua, {Streamson C.} and Scherer, {Philipp E.} and Fnu Nagajyothi",
note = "Funding Information: This study was supported by grants from the United States National Institutes of Health National Institutes of Health (Grants R01-AI-076248, R01-HL-73732 and R21-AI-06538 to H. B. T.; Grants R01-DK55758, R01-CA112023, RC1 DK086629 and P01-DK088761 to P. E. S.; Grants P60-DK020541 and PO1-DK-26687 to S. C. C.); Einstein Diabetes Center (pilot grant to H. B. T.); Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnologico (grant to F. S. M.) and Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de Minas Gerais (grant to F. S. M.).",
year = "2011",
doi = "10.1016/B978-0-12-385895-5.00010-4",
language = "English (US)",
series = "Advances in Parasitology",
publisher = "Academic Press",
pages = "235--250",
booktitle = "Advances in Parasitology",
}
