Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals

C. T. Rubin, E. Capilla, Y. K. Luu, B. Busa, H. Crawford, D. J. Nolan, V. Mittal, C. J. Rosen, Jeffrey E. Pessin, S. Judex

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Obesity, a global pandemic that debilitates millions of people and burdens society with tens of billions of dollars in health care costs, is deterred by exercise. Although it is presumed that the more strenuous a physical challenge the more effective it will be in the suppression of adiposity, here it is shown that 15 weeks of brief, daily exposure to high-frequency mechanical signals, induced at a magnitude well below that which would arise during walking, inhibited adipogenesis by 27% in C57BL/6J mice. The mechanical signal also reduced key risk factors in the onset of type II diabetes, nonesterified free fatty acid and triglyceride content in the liver, by 43% and 39%, respectively. Over 9 weeks, these same signals suppressed fat production by 22% in the C3H.B6-6T congenic mouse strain that exhibits accelerated age-related changes in body composition. In an effort to understand the means by which fat production was inhibited, irradiated mice receiving bone marrow transplants from heterozygous GFP+ mice revealed that 6 weeks of these low-magnitude mechanical signals reduced the commitment of mesenchymal stem cell differentiation into adipocytes by 19%, indicating that formation of adipose tissue in these models was deterred by a marked reduction in stem cell adipogenesis. Translated to the human, this may represent the basis for the nonpharmacologic prevention of obesity and its sequelae, achieved through developmental, rather than metabolic, pathways.

Original languageEnglish (US)
Pages (from-to)17879-17884
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number45
DOIs
StatePublished - Nov 6 2007
Externally publishedYes

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Adipogenesis
Nonesterified Fatty Acids
Obesity
Fats
Congenic Mice
Adiposity
Pandemics
Metabolic Networks and Pathways
Body Composition
Mesenchymal Stromal Cells
Inbred C57BL Mouse
Adipocytes
Health Care Costs
Type 2 Diabetes Mellitus
Walking
Adipose Tissue
Cell Differentiation
Triglycerides
Stem Cells
Bone Marrow

Keywords

  • Diabetes
  • Mesenchymal stem cells
  • Obesity
  • Therapeutics
  • Vibration

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. / Rubin, C. T.; Capilla, E.; Luu, Y. K.; Busa, B.; Crawford, H.; Nolan, D. J.; Mittal, V.; Rosen, C. J.; Pessin, Jeffrey E.; Judex, S.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 45, 06.11.2007, p. 17879-17884.

Research output: Contribution to journalArticle

Rubin, C. T. ; Capilla, E. ; Luu, Y. K. ; Busa, B. ; Crawford, H. ; Nolan, D. J. ; Mittal, V. ; Rosen, C. J. ; Pessin, Jeffrey E. ; Judex, S. / Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 45. pp. 17879-17884.
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