Adherence to zidovudine for the prevention of perinatal transmission in HIV-infected pregnant women

The impact of social network factors, side effects, and perceived treatment efficacy

Penelope A. Demas, Donald M. Thea, Jeremy Weedon, Janis McWayne, Mahrukh Bamji, Genevieve Lambert, Ellie Schoenbaum

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Adherence to zidovudine (ZDV) prophylaxis among 78 pregnant HIV-infected women was measured with 2 physiologic markers. Long-term adherence was measured with blood assays for macrocytosis, a clinical indicator of ZDV use; 53 women (67.9%) were adherent. Short-term adherence was measured with urine assays for ZDV; 48 women (61.5%) were adherent. Comparison of urine assay and interview data indicated that 29% had not taken the last dose that they reported. Participation in HIV support groups and disclosure to the participant's mother were associated with better adherence. These social network factors may enable HIV-infected pregnant women to cope more effectively with the multiple stressors they face and facilitate prenatal care.

Original languageEnglish (US)
Pages (from-to)99-115
Number of pages17
JournalWomen and Health
Volume42
Issue number1
DOIs
StatePublished - 2005

Fingerprint

Zidovudine
Social Support
Pregnant Women
social network
HIV
Urine
Prenatal Care
Self-Help Groups
Disclosure
prophylaxis
Mothers
Interviews
participation
interview
Group

Keywords

  • Adherence
  • HIV
  • Women

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gender Studies

Cite this

Adherence to zidovudine for the prevention of perinatal transmission in HIV-infected pregnant women : The impact of social network factors, side effects, and perceived treatment efficacy. / Demas, Penelope A.; Thea, Donald M.; Weedon, Jeremy; McWayne, Janis; Bamji, Mahrukh; Lambert, Genevieve; Schoenbaum, Ellie.

In: Women and Health, Vol. 42, No. 1, 2005, p. 99-115.

Research output: Contribution to journalArticle

Demas, Penelope A. ; Thea, Donald M. ; Weedon, Jeremy ; McWayne, Janis ; Bamji, Mahrukh ; Lambert, Genevieve ; Schoenbaum, Ellie. / Adherence to zidovudine for the prevention of perinatal transmission in HIV-infected pregnant women : The impact of social network factors, side effects, and perceived treatment efficacy. In: Women and Health. 2005 ; Vol. 42, No. 1. pp. 99-115.
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