Adenosine 3',5'-monophosphate response to parathyroid hormone: Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism

S. J. Marx, Allen M. Spiegel, M. E. Sharp, E. M. Brown, D. G. Gardner, R. W. Downs, M. F. Attie, J. L. Stock

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We investigated cAMP metabolism during and after a 15-min infusion of parathyroid hormone (PTH) in 7 normals, 13 patients with typical primary hyperparathyroidism (1HPT), and 6 patients with familial hypocalciuric hypercalcemia (FHH). Nephrogenous urinary cAMP excretion rate reached a peak during the first or second 30-min urine collection interval after the start of PTH infusion in all subjects. cAMP concentration in plasma reached a peak 5-20 min of the start of the infusion and then decreased with an initial half-time of 15 min. The peak value of nephrogenous urinary cAMP excretion rate was lower in the group with 1HPT than in the group with FHH or in normals (119 vs. 275 vs. 204 nmol/100 ml glomerular filtrate; P < 0.05 for both comparisons). Similarly the peak value of plasma cAMP concentration was less in 1HPT subjects than in FHH patients or in normals (11.1 vs. 17.1 vs. 16.6 nmol/ 100 ml, respectively; P < 0.05 for both comparisons). For purposes of diagnostic classification, the two hypercalcemic groups could be more completely separated by the values of either the renal calcium to creatinine clearance ratio or the plasma PTH concentration than by the values of indices of cAMP response to PTH. The differences in cAMP response to PTH between FHH and 1HPT patients could be secondary to differences in circulating PTH concentrations (these are lower in subjects with FHH) or could reflect a renal lesion more closely related to the underlying etiology of FHH.

Original languageEnglish (US)
Pages (from-to)546-549
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume50
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Primary Hyperparathyroidism
Parathyroid Hormone
Adenosine
Plasmas
Kidney
Urine Specimen Collection
Metabolism
Hypocalciuric hypercalcemia, familial, type 1
Creatinine
Calcium

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Adenosine 3',5'-monophosphate response to parathyroid hormone : Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. / Marx, S. J.; Spiegel, Allen M.; Sharp, M. E.; Brown, E. M.; Gardner, D. G.; Downs, R. W.; Attie, M. F.; Stock, J. L.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 50, No. 3, 1980, p. 546-549.

Research output: Contribution to journalArticle

Marx, S. J. ; Spiegel, Allen M. ; Sharp, M. E. ; Brown, E. M. ; Gardner, D. G. ; Downs, R. W. ; Attie, M. F. ; Stock, J. L. / Adenosine 3',5'-monophosphate response to parathyroid hormone : Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. In: Journal of Clinical Endocrinology and Metabolism. 1980 ; Vol. 50, No. 3. pp. 546-549.
@article{97b83c01b27a45f3b7b10eeef5c7e310,
title = "Adenosine 3',5'-monophosphate response to parathyroid hormone: Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism",
abstract = "We investigated cAMP metabolism during and after a 15-min infusion of parathyroid hormone (PTH) in 7 normals, 13 patients with typical primary hyperparathyroidism (1HPT), and 6 patients with familial hypocalciuric hypercalcemia (FHH). Nephrogenous urinary cAMP excretion rate reached a peak during the first or second 30-min urine collection interval after the start of PTH infusion in all subjects. cAMP concentration in plasma reached a peak 5-20 min of the start of the infusion and then decreased with an initial half-time of 15 min. The peak value of nephrogenous urinary cAMP excretion rate was lower in the group with 1HPT than in the group with FHH or in normals (119 vs. 275 vs. 204 nmol/100 ml glomerular filtrate; P < 0.05 for both comparisons). Similarly the peak value of plasma cAMP concentration was less in 1HPT subjects than in FHH patients or in normals (11.1 vs. 17.1 vs. 16.6 nmol/ 100 ml, respectively; P < 0.05 for both comparisons). For purposes of diagnostic classification, the two hypercalcemic groups could be more completely separated by the values of either the renal calcium to creatinine clearance ratio or the plasma PTH concentration than by the values of indices of cAMP response to PTH. The differences in cAMP response to PTH between FHH and 1HPT patients could be secondary to differences in circulating PTH concentrations (these are lower in subjects with FHH) or could reflect a renal lesion more closely related to the underlying etiology of FHH.",
author = "Marx, {S. J.} and Spiegel, {Allen M.} and Sharp, {M. E.} and Brown, {E. M.} and Gardner, {D. G.} and Downs, {R. W.} and Attie, {M. F.} and Stock, {J. L.}",
year = "1980",
language = "English (US)",
volume = "50",
pages = "546--549",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Adenosine 3',5'-monophosphate response to parathyroid hormone

T2 - Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism

AU - Marx, S. J.

AU - Spiegel, Allen M.

AU - Sharp, M. E.

AU - Brown, E. M.

AU - Gardner, D. G.

AU - Downs, R. W.

AU - Attie, M. F.

AU - Stock, J. L.

PY - 1980

Y1 - 1980

N2 - We investigated cAMP metabolism during and after a 15-min infusion of parathyroid hormone (PTH) in 7 normals, 13 patients with typical primary hyperparathyroidism (1HPT), and 6 patients with familial hypocalciuric hypercalcemia (FHH). Nephrogenous urinary cAMP excretion rate reached a peak during the first or second 30-min urine collection interval after the start of PTH infusion in all subjects. cAMP concentration in plasma reached a peak 5-20 min of the start of the infusion and then decreased with an initial half-time of 15 min. The peak value of nephrogenous urinary cAMP excretion rate was lower in the group with 1HPT than in the group with FHH or in normals (119 vs. 275 vs. 204 nmol/100 ml glomerular filtrate; P < 0.05 for both comparisons). Similarly the peak value of plasma cAMP concentration was less in 1HPT subjects than in FHH patients or in normals (11.1 vs. 17.1 vs. 16.6 nmol/ 100 ml, respectively; P < 0.05 for both comparisons). For purposes of diagnostic classification, the two hypercalcemic groups could be more completely separated by the values of either the renal calcium to creatinine clearance ratio or the plasma PTH concentration than by the values of indices of cAMP response to PTH. The differences in cAMP response to PTH between FHH and 1HPT patients could be secondary to differences in circulating PTH concentrations (these are lower in subjects with FHH) or could reflect a renal lesion more closely related to the underlying etiology of FHH.

AB - We investigated cAMP metabolism during and after a 15-min infusion of parathyroid hormone (PTH) in 7 normals, 13 patients with typical primary hyperparathyroidism (1HPT), and 6 patients with familial hypocalciuric hypercalcemia (FHH). Nephrogenous urinary cAMP excretion rate reached a peak during the first or second 30-min urine collection interval after the start of PTH infusion in all subjects. cAMP concentration in plasma reached a peak 5-20 min of the start of the infusion and then decreased with an initial half-time of 15 min. The peak value of nephrogenous urinary cAMP excretion rate was lower in the group with 1HPT than in the group with FHH or in normals (119 vs. 275 vs. 204 nmol/100 ml glomerular filtrate; P < 0.05 for both comparisons). Similarly the peak value of plasma cAMP concentration was less in 1HPT subjects than in FHH patients or in normals (11.1 vs. 17.1 vs. 16.6 nmol/ 100 ml, respectively; P < 0.05 for both comparisons). For purposes of diagnostic classification, the two hypercalcemic groups could be more completely separated by the values of either the renal calcium to creatinine clearance ratio or the plasma PTH concentration than by the values of indices of cAMP response to PTH. The differences in cAMP response to PTH between FHH and 1HPT patients could be secondary to differences in circulating PTH concentrations (these are lower in subjects with FHH) or could reflect a renal lesion more closely related to the underlying etiology of FHH.

UR - http://www.scopus.com/inward/record.url?scp=0018950106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018950106&partnerID=8YFLogxK

M3 - Article

C2 - 6244324

AN - SCOPUS:0018950106

VL - 50

SP - 546

EP - 549

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -