TY - JOUR
T1 - Adaptation Disrupts Motion Integration in the Primate Dorsal Stream
AU - Patterson, Carlyn A.
AU - Wissig, Stephanie C.
AU - Kohn, Adam
N1 - Funding Information:
This work was supported by the National Institutes of Health (EY016774, EY021371, and P30HD071593) and Research to Prevent Blindness. C.A.P. and S.C.W. were supported in part by an NIH MSTP training grant (T32-GM007288). We thank Amin Zandvakili, Xiaoxuan Jia, and Seiji Tanabe for assistance with data collection.
PY - 2014/2/5
Y1 - 2014/2/5
N2 - Sensory systems adjust continuously to the environment. The effects of recent sensory experience-or adaptation-are typically assayed by recording in a relevant subcortical or cortical network. However, adaptation effects cannot be localized to a single, local network. Adjustments in one circuit or area will alter the input provided to others, with unclear consequences for computations implemented in downstream circuits. Here, we show that prolonged adaptation with drifting gratings, which alters responses in the early visual system, impedes the ability of area MT neurons to integrate motion signals in plaid stimuli. Perceptual experiments reveal a corresponding loss of plaid coherence. A simple computational model shows how the altered representation of motion signals in early cortex can derail integration in MT. Our results suggest that the effects of adaptation cascade through the visual system, derailing the downstream representation of distinct stimulus attributes.
AB - Sensory systems adjust continuously to the environment. The effects of recent sensory experience-or adaptation-are typically assayed by recording in a relevant subcortical or cortical network. However, adaptation effects cannot be localized to a single, local network. Adjustments in one circuit or area will alter the input provided to others, with unclear consequences for computations implemented in downstream circuits. Here, we show that prolonged adaptation with drifting gratings, which alters responses in the early visual system, impedes the ability of area MT neurons to integrate motion signals in plaid stimuli. Perceptual experiments reveal a corresponding loss of plaid coherence. A simple computational model shows how the altered representation of motion signals in early cortex can derail integration in MT. Our results suggest that the effects of adaptation cascade through the visual system, derailing the downstream representation of distinct stimulus attributes.
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U2 - 10.1016/j.neuron.2013.11.022
DO - 10.1016/j.neuron.2013.11.022
M3 - Article
C2 - 24507198
AN - SCOPUS:84893502025
SN - 0896-6273
VL - 81
SP - 674
EP - 686
JO - Neuron
JF - Neuron
IS - 3
ER -