Acyclic ribooxacarbenium ion mimics as transition state analogues of human and malarial purine nucleoside phosphorylases

Erika A. Taylor, Keith Clinch, Peter M. Kelly, Lei Li, Gary B. Evans, Peter C. Tyler, Vern L. Schramm

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Transition state analogues of PNP, the Immucillins and DADMe-Immucillins, were designed to match transition state features of bovine and human PNPs, respectively. A third generation of inhibitors has been designed that contain an acyclic iminoalcohol to replace the cyclic mimic of the ribooxacarbenium ion at the transition states of PNPs. The best third generation inhibitor is equivalent to the best inhibitors found in the previous transition state analogues.

Original languageEnglish (US)
Pages (from-to)6984-6985
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number22
DOIs
StatePublished - Jun 6 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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