Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo

Da Ma; Ben Zhang; Ulrike Hoffmann; Martina Grosse Sundrup; Matthias Eikermann; Lyle Isaacs

doi:10.1002/anie.201206031

Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo

Da Ma, Ben Zhang, Ulrike Hoffmann, Martina Grosse Sundrup, Matthias Eikermann, Lyle Isaacs

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Be My Guest: Two acyclic cucurbit[n]uril-type receptors that carry SO ₃^--groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.

Original language	English (US)
Pages (from-to)	11358-11362
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	45
DOIs	https://doi.org/10.1002/anie.201206031
State	Published - Nov 5 2012
Externally published	Yes

Keywords

cucurbit[n]uril
host-guest systems
medicinal chemistry
molecular recognition
neuromuscular blocking agents

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201206031

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abstract = "Be My Guest: Two acyclic cucurbit[n]uril-type receptors that carry SO 3--groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.",

keywords = "cucurbit[n]uril, host-guest systems, medicinal chemistry, molecular recognition, neuromuscular blocking agents",

author = "Da Ma and Ben Zhang and Ulrike Hoffmann and Sundrup, {Martina Grosse} and Matthias Eikermann and Lyle Isaacs",

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doi = "10.1002/anie.201206031",

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volume = "51",

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AU - Ma, Da

AU - Zhang, Ben

AU - Hoffmann, Ulrike

AU - Sundrup, Martina Grosse

AU - Eikermann, Matthias

AU - Isaacs, Lyle

PY - 2012/11/5

Y1 - 2012/11/5

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AB - Be My Guest: Two acyclic cucurbit[n]uril-type receptors that carry SO 3--groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.

KW - cucurbit[n]uril

KW - host-guest systems

KW - medicinal chemistry

KW - molecular recognition

KW - neuromuscular blocking agents

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ER -

Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo

Abstract

Keywords

ASJC Scopus subject areas

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