Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo

Da Ma, Ben Zhang, Ulrike Hoffmann, Martina Grosse Sundrup, Matthias Eikermann, Lyle Isaacs

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

Be My Guest: Two acyclic cucurbit[n]uril-type receptors that carry SO 3--groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.

Original languageEnglish (US)
Pages (from-to)11358-11362
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number45
DOIs
StatePublished - Nov 5 2012
Externally publishedYes

Keywords

  • cucurbit[n]uril
  • host-guest systems
  • medicinal chemistry
  • molecular recognition
  • neuromuscular blocking agents

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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